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Anemia 1.6 X more likely during pregnancy if low Vitamin D – meta-analysis Dec 2021

Vitamin D deficiency and anemia in pregnant women: a systematic review and meta-analysis

Nutrition Reviews, nuab114, https://doi.org/10.1093/nutrit/nuab114
Michele S Lima, Marcos Pereira, Caroline T Castro, Djanilson B Santos

Epidemiological studies suggest an association between vitamin D deficiency and anemia. Evidence of this relationship in pregnant women, however, is scarce.

The aim of this systematic review was to investigate the association between vitamin D deficiency and gestational anemia through observational studies.

Data Sources
The PubMed, Scopus, Web of Science, ScienceDirect, Embase, and Virtual Health Library databases were searched from inception to April 2021.

Study Selection
Original articles reporting observational studies that investigated the association between vitamin D deficiency and gestational anemia were included. Articles that did not have an abstract, as well as reviews articles, experimental studies, and editorials, were excluded. Two reviewers independently performed study selection, data extraction, and assessment of study quality. Disagreements between the reviewers were resolved by a third reviewer.

Data Extraction
Study quality was assessed by 2 scales. Data were extracted from eligible studies and arranged in a 2 × 2 table. Odds ratios with 95% confidence intervals for the risk of the outcome were estimated using a fixed-effect model.

In total, 985 studies were retrieved, of which 17 were included in the systematic review:

  • 11 cohort studies,
  • 3 case‐control studies, and
  • 3 cross-sectional studies.

For the meta-analysis, 8 studies with a total of 6530 women were included. There was a 61% increase in the odds of anemia in pregnant women with vitamin D deficiency (OR = 1.61; 95%CI, 1.41–1.83; I2 = 48%).

Vitamin D deficiency may be a risk factor for anemia in pregnant women.

Systematic Review Registration PROSPERO registration no. CRD42020182697.

VitaminDWiki - Overview Iron Supplements and Vitamin Danemia health problems

Diseases associated with

Low iron (menstruating) High iron (males)
Anemia Anemia of chronic disease
Fibromyalgia Premature aging
Inflammatory bowel disease Atherosclerosis
Hypothyroidism Anorexia
Depression / anxiety Grave's disease
Attention deficit hyperactivity disorder Heart arrhythmia
Parkinson's disease Cancer
Neurodegenerative conditions Sideroblastic anemia
Celiac disease Nonalcoholic fatty liver disease (NAFLD).
Excess dietary fructose is a primary initiator of NAFLD,
but high iron is another culprit that triggers disease progression
Restless leg syndrome Liver damage and liver disease
Hair loss Still's disease
Muscle weakness, decline in motor skills Hemochromatosis
Mental changes and memory loss Hemophagocytic syndrome

Vitamin D pages containing "anemia" in title (17 as of Jan 2022)

Items found: 18
Title Modified
Anemia 8X more likely in infants if low vitamin D – Sept 2023 07 Sep, 2023
Anemia 1.6 X more likely during pregnancy if low Vitamin D – meta-analysis Dec 2021 02 Jan, 2022
Anemia in pregnant teens 7X more likely if low vitamin D – April 2015 28 Nov, 2021
Anemia is assocated with both very low and very high vitamin D (Mexican seniors) – Oct 2021 28 Nov, 2021
Anemia in children 3.5 X more likely if low vitamin D – March 2018 21 Nov, 2018
Anemia (in heart failure) not treated by Vitamin D (they should have added Iron) – RCT Aug 2017 25 Aug, 2017
Sickle Cell Anemia: 64 percent had less than 10ng of vitamin D – April 2012 06 Mar, 2017
Those with Ulcerative colitis and low vitamin D were 3.3X more likely to have anemia – Oct 2013 18 Jan, 2017
Hypothesis: Iron deficiency anemia results in reduced vitamin D in blood 19 Jun, 2016
Low vitamin D - anemia 2.2X more likely (no surprise) – meta-analysis Aug 2015 28 Aug, 2015
Anemia perhaps results in low vitamin D for premenosausal women – March 2013 28 Aug, 2015
Inflammation Anemia in Blacks 8X more likely if less than 20 ng of vitamin D – April 2015 22 Aug, 2015
Anemia 1.9X more likely in white children having lowish vitamin D – Jan 2014 10 Aug, 2015
2X increased chance of anemia (low iron) associated with low vitamin D – Sept 2013 17 Apr, 2015
Infants who have iron deficiency anemia are 4X more likely to be vitamin D deficient – March 2013 15 Dec, 2014
Anemia associated with lower than 20 ng vitamin D among elderly – Jan 2011 15 Dec, 2014
Having celiac disease and low vitamin D only predicted psoriasis and anemia – Jan 2013 10 Jul, 2014
Another indiction that lower level of vitamin D are OK in blacks – Anemia Oct 2013 13 Oct, 2013

Created by admin. Last Modification: Sunday January 2, 2022 20:16:19 GMT-0000 by admin. (Version 6)