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Worse COVID during 3Q pregnancy if 2.5 ng lower Vitamin D – meta-analysis Sept 2022


Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta- analysis

Clinical Nutrition ESPEN, September 2022, DOI: 10.1016/j.clnesp.2022.09.008
Sadegh Mazaheri-Tehrani, Mohammad Hossein Mirzapour, Maryam Yazdi, Mohammad Fakhrolmobasheri, Amir Parsa Abhari

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Background: Serum vitamin D level is reported to be associated with the risk of incidence, and severity of COVID-19 in the general population. During pregnancy, immune system alterations in line with changes in vitamin D metabolism may affect the course of COVID-19. Thus, we aimed to systematically review the association between vitamin D, pregnancy, and COVID-19.

Methods: A systematic literature search was conducted in PubMed, Scopus, Web of Science, Embase, and Google Scholar until the end of May 2022. Mean differences (MD) with 95% CI were used as desired effect sizes to assess the association of serum vitamin D levels with risk of incidence and severity of COVID-19 in pregnant women.

Results: Among 259 records, 7 and 6 studies were included in the systematic review and metaanalysis, respectively. All included studies had acceptable quality. Our results demonstrated an insignificant difference between infected women and non-infected controls (MD =-2.55 ng/ml, 95% CI: -6.85 - 1.74). But serum vitamin D levels in severe/moderate cases compared to mild ones (MD=-2.71 ng/ml, 95% CI: -4.16 - -1.25) is significantly lower.

Conclusion: Based on the current evidence, serum vitamin D level does not associate with risk of SARS-CoV-2 infection among pregnant women, but we find a significant association with the severity the of disease. These findings may be helpful in similar conditions and future studies to better understand the complex immune alterations during pregnancy.
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VitaminDWiki - 20 studies in both categories Virus and Pregnancy

This list is automatically updated


VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of Sept 28 2022, the VitaminDWiki COVID page had:  34 trials 14 trial results,   37 meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   26 risk factors are ALL associated with low Vit D,   Recent Virus pages   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   116 COVID Clinical Trials using Vitamin D (08/2022)
5 most-recently changed Virus entries

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VitaminDWiki – 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D includes pregnancy

CDC: Confirms Low Vitamin D
VitaminDWiki and other
Cancer VitaminDWiki 7X
Chronic kidney diseaseVitaminDWiki
COPD & other lung problemsPneumonia - VDW
Lung Death 4X
Down Syndrome VitaminDWiki - deficiency
Heart conditionsVitaminDWiki
Immunocompromised stateVitamin D helps organ transplant
Cancer - After diagnosis
Obesity Overview Obesity and Vitamin D
PregnancyOverview Pregnancy and vitamin D
Sickle cell diseaseOverview Sickle Cell and Vitamin D
Smoking Smoking reduces vitamin D - many studies
Diabetes T2VitaminDWiki
CDC: Might be factors
Asthma Overview Asthma and Vitamin D
Cerebrovascular disease Cardiovascular   Stroke
Cystic fibrosisCystic Fibrosis
Hypertension VitaminDWiki
ACE inhibitors VitaminDWiki 4X
Neurologic conditions,
such as dementia
Overview Alzheimer's-Cognition and Vitamin D
Liver diseaseOverview Liver and vitamin D
Pulmonary fibrosisPulmonary Fibrosis
Thalassemia VitaminDWiki - deficiency
Diabetes T1 T1 Diabetes
CDC: Still fails to mention
AgeOverview Seniors and Vitamin D
Nursing HomeWikipedia
PrisonsWikipedia
Dark SkinVitaminDWiki
Vertebral Fracture VitaminDWiki
Shift workVitaminDWiki 2X
Mood disorders Note:
Low D ==> depression
1.5X increase in COVID-19 death
Concealing clothingVitaminDWiki 3.5X
Schizophrenia 3X mortalityVitaminDWiki Low D since birth

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Sometimes A health problem will cause a Vitamin D deficiency
Sometimes A Vitamin D deficiency will cause another health problem
AlwaysStop a vitamin D deficiency to avoid getting additional health problems


Attached files

ID Name Comment Uploaded Size Downloads
18421 Moderate vs mild COVID.jpg admin 13 Sep, 2022 10:46 28.42 Kb 62
18420 D during COVID-19 during pregnancy_CompressPdf.pdf PDF 2022 admin 13 Sep, 2022 10:46 346.41 Kb 12
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