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Birth size and weight increased by Vitamin D – meta-analysis Feb 2019

Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients 2019, 11(2), 442; https://doi.org/10.3390/nu11020442
(This article belongs to the Special Issue The Role of Pregnancy Nutrition in Maternal and Offspring Health)


It is amazing that a benefit was found when so many of the trials gave such small amounts of vitamin D, and somewhat late in pregnancy

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

The articles in Pregnancy AND Meta-analysis are here:

Ensure a healthy pregnancy and baby - take Vitamin D before conception has the following
Start Vitamin D soon if pregnant VDW 9923

 Download the PDF from VitaminDWiki

During pregnancy, vitamin D supplementation may be a feasible strategy to help prevent low birthweight (LBW) and small for gestational age (SGA) births. However, evidence from randomized controlled trials (RCTs) is inconclusive, probably due to heterogeneity in study design and type of intervention. A systematic literature search in the PubMed-Medline, EMBASE, and Cochrane Central Register of Controlled
Trials databases was carried out to evaluate the effects of oral vitamin D supplementation during pregnancy on birthweight, birth length, head circumference, LBW, and SGA. The fixed-effects or random-effects models were used to calculate mean difference (MD), risk ratio (RR), and 95% Confidence Interval (CI).
On a total of 13 RCTs, maternal vitamin D supplementation had a positive effect on

  • birthweight (12 RCTs; MD = 103.17 g, 95% CI 62.29–144.04 g),
  • length (6 RCTs; MD = 0.22 cm, 95% CI 0.11–0.33 cm), and
  • head circumference (6 RCTs; MD:0.19 cm, 95% CI 0.13–0.24 cm).

In line with these findings, we also demonstrated that maternal vitamin D supplementation reduced the risk of
(LBW (3 RCTs; RR = 0.40, 95% CI 0.22–0.74) and

  • SGA (5 RCTS; RR = 0.69, 95% CI 0.51–0.92).

The present systematic review and meta-analysis confirmed the well-established effect of maternal vitamin D supplementation on birth size. However, further research is required to better define risks and benefits associated with such interventions and the potential implications for public health

Created by admin. Last Modification: Wednesday February 20, 2019 14:05:27 GMT-0000 by admin. (Version 2)

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11431 Birth size-compressed.pdf PDF 2019 admin 20 Feb, 2019 14:01 555.03 Kb 2938