Toggle Health Problems and D

Need at least 6,000 IU daily while breastfeeding to eliminate Vitamin D deficiency – meta-analysis Oct 2021

The Effect of Maternal Vitamin D Supplementation on Vitamin D Status of Exclusively Breast Feeding Mothers and Their Nursing Infants: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Adv Nutr. 2021 Oct 28;nmab126. doi: 10.1093/advances/nmab126
Elham Kazemain 1, Samaneh Ansari 2, Sayed Hossein Davoodi 3 4, William B Patterson 5, Pedram Shakerinava 6, Carol L Wagner 7, Atieh Amouzegar 6

The optimal vitamin D supplementation plan during lactation is unclear. We investigated the effect of maternal vitamin D supplementation on mother-infant dyads' vitamin D status during lactation. All controlled trials that compared vitamin D supplements to placebo or low doses of vitamin D in breastfeeding mothers were included. Pooled effect size and the associated 95% confidence interval (CI) for each outcome were estimated using random-effects models. A one-stage random-effect dose-response model was used to estimate the dose-response relation across different vitamin D dosages and serum 25-hydroxy vitamin D (25(OH)D) concentrations.

We identified 19 clinical trials with 27 separate comparison groups (n = 3337 breastfeeding mothers). Maternal vitamin D supplement dosages were associated with circulating 25(OH)D concentrations in breastfeeding women in a non-linear fashion. Supplementation with 1000 IU of vitamin D/day increased serum 25(OH)D concentrations by 7.8 ng/mL while there was a lower increase in concentrations at vitamin D doses of >2000 IU/day (3.07 and 2.05 ng/mL increases between 2000 to 3000 and 3000 to 4000 IU/day, respectively). A linear relationship was observed between maternal vitamin D supplementation dosage and the infants' circulating 25(OH)D concentrations.

Each additional 1000 IU of maternal vitamin D intake was accompanied by a 2.7 ng/mL increase in serum 25(OH)D concentration in their nursing infants. The subgroup analysis showed that maternal vitamin D supplementation was accompanied by a statistically significant increase in infants' 25(OH)D concentration in the trials with a duration of >20 weeks, vitamin D supplementation >1000 IU/day, East Indian participants, maternal BMI <25 kg/m2, and studies with an overall low risk of bias.

Long-term maternal supplementation with vitamin D at a high dose (>6000 IU/day) effectively corrected vitamin D deficiency in both mothers and infants. Nevertheless, infants with 25(OH)D concentrations over 20 ng/mL may require a relatively low maternal dose to maintain vitamin D sufficiency.

Statement of significance: This study is the first dose-response analysis on the relation between circulating 25-hydroxy vitamin D (25(OH)D) and maternal vitamin D supplementation in mother-infant dyads. We also considered factors such as study design and population characteristics that may affect the outcomes of a given vitamin D trial that have been overlooked in previous reviews.

VitaminDWiki pages with BREASTFEEDING OR WAGNER in title (20 as of Nov 2021)

This list is automatically updated

Items found: 25
Title Modified
Vitamin D levels of breastfeeding mothers and infants in 3 cities – Feb 2015 29 Aug, 2023
Breastfeeding and Vitamin D - many studies 29 Aug, 2023
Need at least 6,000 IU of Vitamin D daily during pregnancy and breastfeeding (Wagner) – meta-analysis March 2022 15 Apr, 2022
Monthly 120,000 IU of Vitamin D while breastfeeding was good – RCT Jan 2022 11 Jan, 2022
Breastfeeding is almost always associated with infant vitamin D deficiency – Dec 2021 14 Dec, 2021
Need at least 6,000 IU daily while breastfeeding to eliminate Vitamin D deficiency – meta-analysis Oct 2021 01 Nov, 2021
6,400 IU of Vitamin D is safe and effective during breastfeeding – RCT Dec, 2020 16 Dec, 2020
COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 29 Apr, 2020
Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020 12 Jan, 2020
Omega-3 during pregnancy and breastfeeding is recommended – May 2019 23 May, 2019
Vitamin D during lactation – 6,000 IU mom or 400 IU infant (Hollis, Wagner chapter) – Aug 2018 09 Aug, 2018
Biochemical rickets non-existent if breastfeeding mother got 600,000 IU of vitamin D (3 dollars) – RCT Dec 2017 03 Mar, 2018
Extended breastfeeding cut in half the risk of Multiple Sclerosis – July 2017 28 Nov, 2017
Pregnant women need at least 40 ng of Vitamin D (Wagner, genes) – Oct 2017 08 Nov, 2017
Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016 13 Sep, 2017
Vitamin D alters genes during pregnancy – Hollis and Wagner Sept 2017 10 Aug, 2017
Breastfeeding mothers and Vitamin D: supplement only themselves usually, 4 out of 10 used monthly rather than daily – Jan 2017 05 Aug, 2017
Low Vitamin D results in adverse pregnancy and birth outcomes – Wagner meta-analysis March 2017 19 Mar, 2017
Breastfeeding mother getting 6400 IU of Vitamin D is similar to infant getting 400 IU – RCT Sept 2015 25 Jan, 2017
Breastfeeding exclusively may not be best strategy for bone health (if not add vitamin D) – Feb 2016 16 Feb, 2016
NutraIngredients.com Breastfeeding exclusively may not be best strategy for bone health (if not add vitamin D) - Feb 2016 16 Feb, 2016
Breastfeeding with daily or monthly doses of vitamin D virtually the same – RCT Dec 2013 01 Feb, 2014
Breastfeeding with daily or monthly doses of vitamin D fairly similar – Dec 2013 14 Dec, 2013
6400 IU vitamin D is effective during breastfeeding – Oct 2010 14 Dec, 2013
Hypothesis – vitamin D links breastfeeding difficulties and depression – July 2011 19 Jul, 2011

Pregnancy category starts with

860 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D starts with

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Pregnancy and Meta-analysis studies in VitaminDWiki

Created by admin. Last Modification: Monday November 1, 2021 11:08:07 GMT-0000 by admin. (Version 5)