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Birth weight and length increased with high levels of vitamin D – meta-analysis March 2015

Erratum of the study - June 2016 - charts with the following text

The new pooled analysis showed the effect of vitamin D is larger with the same direction for

  • circulating 25-OHD (mean difference [MD], 70.69 vs. 66.46 nmol/L),
  • preeclampsia (relative risk [RR], 0.89 vs. 0.88),
  • gestational diabetes (RR, 1.08 vs. 1.05),
  • low birth weight (RR, 0.84 vs. 0.72),
  • preterm birth (RR, 1.30 vs. 1.26),
  • birth weight (MD,108.62 vs. 107.60 g), and
  • birth length (MD, 0.79 vs. 0.30 cm).

The new pooled analysis shows that the effect of vitamin D is smaller with the same direction for small for gestation age (RR, 0.69 vs. 0.78).
 Download the Erratum from VitaminDWiki
   Strangely this erratum is not mentioned at the web site for the original publication

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Fertility and Sterility, Received: October 19, 2014; Received in revised form: February 11, 2015; Accepted: February 12, 2015; Published Online: March 24, 2015, DOI: http://dx.doi.org/10.1016/j.fertnstert.2015.02.019
Faustino R. Pérez-López, M.D., Ph.D. faustino.perez at unizar.es, Vinay Pasupuleti, M.D., Ph.D., Edward Mezones-Holguin, M.D., Vicente A. Benites-Zapata, M.D., Priyaleela Thota, M.D., Abhishek Deshpande, M.D., Ph.D., Adrian V. Hernandez, M.D., Ph.D.

See also

Many of the RCT studied used very small doses of D3 or used D2 - so could not be expected to get high enough levels to make a difference. See BOLDED references for details
Virtually no Meta-analysis considers dose size

VitaminDWiki articles in Pregnancy AND Meta-analysis:


Objective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables.

Design: Systematic review and meta-analysis of randomized controlled trials (RCTs).

Setting; Not applicable.

Patient(s): Pregnant women and neonates.

Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation ± calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy.

Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs).

Result(s): Thirteen RCTs (n = 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7).
Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference:

  • 107.6 g (95% CI 59.9–155.3 g) and
  • 0.3 cm (95% CI 0.10–0.41 cm), respectively.

Incidence of

  • preeclampsia,
  • GDM,
  • SGA,
  • low birth weight,
  • preterm birth, and
  • cesarean section

were not influenced by vitamin D supplementation.
Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous.

Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion.

 Download the PDF from VitaminDWiki


Note: the Authors of the RCT used by the meta-analysis are bolded by VitaminDWiki, along with details

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Attached files

ID Name Comment Uploaded Size Downloads
7487 Erratum.pdf admin 15 Dec, 2016 1.19 Mb 685
5721 Effect of vitamin supplementation during pregnancy - Meta-analysis of RCTs.pdf admin 27 Jul, 2015 2.04 Mb 1286
5360 ROTH.pdf admin 21 Apr, 2015 4.02 Mb 1005