Loading...
 
Toggle Health Problems and D

Pregnancy and offspring health - umbrella of 250,000 pregnancies - meta-analysis May 2024


Nutrition & Diabetes volume 14, Article number: 35 (2024)
Mei-Chun Chien, Chueh-Yi Huang, Jie-Huei Wang, Chia-Lung Shih & Pensee Wu

Vitamin D LEVEL
Image
Image

Vitamin D DOSE
Image
Background
Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes.

Objective
To summarize systematic reviews and meta-analyses evaluating the effects of vitamin D deficiency and of vitamin D supplementation in pregnancy on maternal and offspring health-related outcomes.

Methods
Prior to conducting this umbrella review, we registered the protocol in PROSPERO (CRD42022368003). We conducted searches in PubMed, Embase, and Cochrane Library for systematic reviews and meta-analyses on vitamin D in pregnancy, from database inception to October 2, 2023. All outcomes related to vitamin D in pregnancy obtained from the systematic reviews and meta-analyses were extracted. Data Extraction: Two reviewers independently chose studies and collected information on health outcomes. The quality of the included articles’ methodology was assessed using AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews–2).

Results
We identified 16 eligible systematic reviews and meta-analyses, which included 250,569 women. Our results demonstrated that vitamin D deficiency in pregnancy is associated with increased risk of preterm birth, small-for gestational age/low birth weight infants, recurrent miscarriage, bacterial vaginosis and gestational diabetes mellitus. Vitamin D supplementation in pregnancy increases birth weight, and reduces the risk of maternal pre-eclampsia, miscarriage, and vitamin D deficiency, fetal or neonatal mortality, as well as attention-deficit hyperactivity disorder, and autism spectrum disorder in childhood. In women with gestational diabetes mellitus, vitamin D supplementation in pregnancy can reduce the risk of maternal hyperbilirubinemia, polyhydramnios, macrosomia, fetal distress, and neonatal hospitalization.

Conclusion
Due to the association with adverse maternal and offspring health outcomes, we recommend the vitamin D status in pregnancy should be monitored, particularly in women at high risk of vitamin D deficiency. It is suggested that pregnant women take a dose of >400 IU/day of vitamin D supplementation during pregnancy to prevent certain adverse outcomes.
 Download the PDF from VitaminDWiki


VitaminDWiki - 55 Pregnancy Meta-analyses

This list is automatically updated


VitaminDWiki - Pregnancy category contains

897 items in Pregnancy category

 - see also


VitaminDWiki – Healthy pregnancies need lots of vitamin D contains

Problem
Vit. D
Reduces
Evidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


Attached files

ID Name Comment Uploaded Size Downloads
21267 Umbrella T3.webp admin 04 Jun, 2024 89.17 Kb 19
21266 Umbrella T2-2.webp admin 04 Jun, 2024 23.77 Kb 15
21265 Umbrella T2-1.webp admin 04 Jun, 2024 75.00 Kb 17
21264 Pregnancy offspring D meta_CompressPdf.pdf admin 04 Jun, 2024 336.31 Kb 7