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Less labor pain if higher level of vitamin D – August 2021

Effect of intrapartum vitamin D levels on labor pain

J Obstet Gynaecol Res. 2021 Aug 9. doi: 10.1111/jog.14960    Publisher will rent the PDF for $14
Refika G Koyucu 1, Tuğba Özcan 2
Zero pain at 2-3 cm with 50 ng?



Fact: Higher Vitamin D improves pregnancies and infant health
Fact: Higher Vitamin D reduces pain
This study observes Higher Vitamin D asscociated with lower pain during labor

Note: 40-60 ng is a good level of vitamin D for life as well as pregnancy

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

0 - 10 Pain Scale from web

See also web


Aim: Vitamin D has widespread receptor distribution in the body, and therefore it has vital roles in numerous pathophysiological conditions. It also affects pain manifestation through its functions at various stages of the pain pathways. This study aimed to investigate the effects of intrapartum vitamin D levels on pain experienced by women during the first stage of labor.

Methods: A total of 127 term-nulliparous women at the early stage of labor were included in the study. Serum 25 (OH) vitamin D levels were measured at the beginning of labor to determine intrapartum vitamin D levels. Labor pain was assessed using the Visual Analog Scale at different stages of cervical dilation (VAS0 , VAS1 , VAS2 ). Postpartum pain (VASpp ) and women's birth satisfaction score (BSS) were also evaluated during the early postpartum period.

Results: There was a moderate negative correlation between vitamin D and VAS0 and VAS1 (r2 = 0.4, p = 0.000; r2 = -0.570, p = 0.000, respectively), and a weak negative correlation between vitamin D and VAS2 (r2 = -0.373, p = 0.000). No significant correlation was found between vitamin D and BSS and length of labor (p = 0.127, p = 0.126, respectively).

Conclusion: In nulliparous women with low vitamin D levels, the first stage of labor and the early postpartum period may be more painful. To facilitate management of labor pain, during the antenatal period vitamin D levels should be monitored, and in cases where the levels are deficient, vitamin D supplementation should be started.


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