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2X more likely to have preeclampsia if less than 20 ng of vitamin D – Meta-analysis Jan 2013

Maternal Vitamin D Status and Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis.

J Matern Fetal Neonatal Med. 2013 Jan 13.
Wei SQ, Qi HP, Luo ZC, Fraser WD.
Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Canada;

OBJECTIVE: To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes.

STUDY DESIGN: We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: 'vitamin D' and 'status' or 'deficiency' or 'insufficiency' and 'pregnancy'. A systematic review and meta-analysis were conducted on observational studies that reported the association between maternal blood vitamin D levels and adverse pregnancy outcomes including preeclampsia, gestational diabetes mellitus, preterm birth or small-for-gestational age.

RESULTS: Twenty-four studies met the inclusion criteria. Women with circulating 25-hydroxyvitamin D [25(OH)D] level less than 50 nmol/l in pregnancy experienced an increased risk of

  • preeclampsia [OR 2.09 (95%CI 1.50 -2.90)],
  • gestational diabetes mellitus [OR 1.38 (1.12-1.70)],
  • preterm birth [OR 1.58 (1.08-2.31)] and
  • small-for-gestational age [OR 1.52 (1.08-2.15)].

CONCLUSION: Low maternal vitamin D levels in pregnancy may be associated with an increased risk of preeclampsia, gestational diabetes mellitus, preterm birth and small-for-gestational age.

PMID: 23311886


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See also VitaminDWiki

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