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Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019

Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data

European Respiratory Journal 2019; DOI: 10.1183/13993003.02003-2018
David A. Jolliffe, Davaasambuu Ganmaa, Christian Wejse, Rubhana Raqib, Md. Ahsanul Haq, Nawal Salahuddin, Peter K. Daley, Anna P. Ralph, Thomas R. Ziegler, Adrian R. Martineau


Items in both categories TB and Radomized Controlled Trials are listed here:

Items in both categories TB and Meta-analysis are listed here:

From Press Release
10.0 million people developed active tuberculosis worldwide in 2017,
Multi-drug resistant (MDR) TB.occurred in ~500,000 cases. (5%)

  • "Lead researcher Professor Adrian Martineau from Queen Mary University of London said: "Multi-drug resistant TB is on the rise globally. It's notoriously difficult to treat, and it carries a much worse prognosis than standard TB."
  • "By adding vitamin D to antibiotic treatment, we can boost the immune system to help the body to clear TB bugs, rather than relying on antibiotics on their own to kill the bacteria directly"

 Download the PDF from Sci-Hub via VitaminDWiki
Vitamin D dosing varied widely: daily, weekly, infrequently, and single
Background Randomised controlled trials (RCTs) of adjunctive vitamin D in pulmonary tuberculosis (PTB) treatment have yielded conflicting results. Individual participant data (IPD) meta-analysis could identify factors explaining this variation.

Methods We meta-analysed IPD from RCTs of vitamin D in patients receiving antimicrobial therapy for PTB. Primary outcome was time to sputum culture conversion. Secondary outcomes were time to sputum smear conversion, mean 8-week weight and incidence of adverse events. Pre-specified sub-group analyses were done according to baseline vitamin D status, age, sex, drug-susceptibility, HIV status, extent of disease, and vitamin D receptor genotype.

Results IPD were obtained for 1850 participants in 8 studies. Vitamin D did not influence time to sputum culture conversion overall (aHR 1.06, 95% CI 0.91–1.23), but it did accelerate sputum culture conversion in participants with multidrug-resistant PTB (aHR 13.44, 95% CI 2.96–60.90); no such effect was seen in those whose isolate was sensitive to rifampicin and/or isoniazid (aHR 1.02, 95% CI 0.88–1.19; Pinteraction=0.02). Vitamin D accelerated sputum smear conversion overall (aHR 1.15, 95% CI 1.01–1.31), but did not influence other secondary outcomes.

Conclusions Vitamin D did not influence time to sputum culture conversion overall, but it accelerated sputum culture conversion in patients with multidrug-resistant PTB.

Attached files

ID Name Comment Uploaded Size Downloads
11350 TB doses.jpg admin 07 Feb, 2019 11:02 54.85 Kb 470
11349 TB drug resistant.jpg admin 07 Feb, 2019 10:43 83.22 Kb 426
11348 TB drug resistant.pdf PDF 2019 admin 07 Feb, 2019 10:43 1.02 Mb 545
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