Toggle Health Problems and D

Wondering about tuberculosis and Vitamin D in Australia – Nov 2013

Vitamin D and Vitamin D and tuberculosis: hope or hype?

Med J Aust 2013; 199 (10): 648-649. Doi: 10.5694/mja13.11174
Anna P Ralph, MPH, FRACP, PhD, Clinical Research Fellow1
Robyn M Lucas, MB ChB, PhD, FAFPHM, Associate Professor2
1 Global and Tropical Health, Menzies School of Health Research, Darwin, NT.
2 National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT.

It may be worthwhile to test for and treat vitamin D deficiency in latent infection, but not in active TB

No abstract outside of the paywall


  • 1. MacLachlan JH, Cowie BC. Epidemiology of tuberculosis and levels of vitamin D in Australia: person, place and time. Med J Aust 2013; 199: 655-656.
  • 2. MacLachlan JH, Lavender CJ, Cowie BC. Effect of latitude on seasonality of tuberculosis, Australia, 2002-2011. Emerg Infect Dis 2012; 18: 1879-1881.
  • 3. Ralph AP, Lucas RM, Norval M. Vitamin D and solar ultraviolet radiation in the risk and treatment of tuberculosis. Lancet Infect Dis 2013; 13: 77-88.
  • 4. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311: 1770-1773.
  • 5. Ralph AP, Kelly PM, Anstey NM. L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol 2008; 16: 336-344.
  • 6. Selvaraj P, Prabhu Anand S, Harishankar M, Algarasu K. Plasma 1,25 dihydroxy vitamin D3 level and expression of vitamin D receptor and cathelicidin in pulmonary tuberculosis. J Clin Immunol 2009; 29: 470-478.
  • 7. Conesa-Botella A, Meintjes G, Coussens AK, et al. Corticosteroid therapy, vitamin D status, and inflammatory cytokine profile in the HIV-tuberculosis immune reconstitution inflammatory syndrome. Clin Infect Dis 2012; 55: 1004-1011.
  • 8. Ralph AP, Waramori G, Pontororing GJ, et al. L-arginine and vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial. PLOS One 2013; 8: e70032.
  • 9. Wejse C, Gomes VF, Rabna P, et al. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 2009; 179: 843-850.
  • 10. Martineau AR, Timms PM, Bothamley GH, et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011; 377: 242-250.
  • 11. Lavender TW, Martineau AR, Quinton R, Schwab U. Severe hypercalcaemia following vitamin D replacement for tuberculosis-associated hypovitaminosis D. Int J Tuberc Lung Dis 2012; 16: 140.
  • 12. Coussens AK, Wilkinson RJ, Hanifa Y, et al. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. Proc Natl Acad Sci U S A 2012; 109: 15449-15454.
  • 13. Nursyam EW, Amin Z, Rumende CM. The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med Indones 2006; 38: 3-5.
  • 14. Salahuddin N, Ali F, Hasan Z, et al. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study Supplementary Cholecalciferol in recovery from tuberculosis. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infect Dis 2013; 13: 22.
  • 15. Talat N, Perry S, Parsonnet J, et al. Vitamin D deficiency and tuberculosis progression. Emerg Infect Dis 2010; 16: 853-855.
  • 16. Vieth R. Vitamin D nutrient to treat TB begs the prevention question. Lancet 2011; 377: 189-190.
  • 17. Royal College of Pathologists of Australasia. Use and interpretation of vitamin D testing. Position statement. May 2013. http://www.aims.org.au/documents/item/347 (accessed Sep 2013).
  • 18. Perterlik M. Vitamin D insufficiency and chronic diseases: hype and reality. Food Funct 2012; 3: 784-794.
  • 19. Michaëlsson K, Baron JA, Snellman G, et al. Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am J Clin Nutr 2010; 92: 841-848.
  • 20. Dror Y, Giveon SM, Hoshen M, et al. Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. J Clin Endocrinol Metab 2013; 98: 2160-2167.
  • 21. Nielsen NO, Skifte T, Andersson M, et al. Both high and low serum vitamin D concentrations are associated with tuberculosis: a case-control study in Greenland. Br J Nutr 2010; 104: 1487-1491.
  • 22. Cannell J. Why should you keep your vitamin D level around 50 ng/ml? Vitamin D Council Newsletter 2011, 23 Sep.

See also VitaminDWiki