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Children with active TB were 4.6X more likely to have low vitamin D – Dec 2014

Vitamin D and tuberculosis: a multicenter study in children

BMC Infectious Diseases 2014, 14:652 doi:10.1186/s12879-014-0652-7
Elisabetta Venturini 1, Ludovica Facchini 1, Nuria Martinez-Alier 2, Vas Novelli 3, Luisa Galli 1,
Maurizio de Martino 1 maurizio.demartino at unifi.it and Elena Chiappini 1

Background The aim of this study is to evaluate vitamin D levels in children with latent and active TB compared to healthy controls of the same age and ethnical background.

Methods A multicenter observational study has been conducted in three tertiary care paediatric centres: Anna Meyer Children's University Hospital, Florence, Italy; Evelina London Children's Hospital, London, United Kingdom and Great Ormond Street Hospital, London, United Kingdom. Vitamin D was considered deficient if the serum level was <25?nmol/L, insufficient between 25 and 50?nmol/L and sufficient for a level >50?nmol/L.

Results The study population included 996 children screened for TB, which have been tested for vitamin D. Forty-four children (4.4%) had active TB, 138 (13.9%) latent TB and 814 (81.7%) were controls. Our study confirmed a high prevalence of hypovitaminosis D in the study population. A multivariate analysis confirmed an increased risk of hypovitaminosis D in children with latent and active TB compared to controls [(P?=?0.018; RR?=?1.61; 95%CI: 1.086-2.388), (P?<?0.0001; RR?=?4.587; 95%CI:1.190-9.608)].

Conclusions Hypovitaminosis D was significantly associated with TB infection in our study. Further studies are needed to evaluate a possible role of vitamin D in the treatment and prevention of tuberculosis in children.
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Children with active TB were 4.6X more likely to have low vitamin D – Dec 2014

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- Overview Tuberculosis and Vitamin D Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015 Low vitamin D is a risk factor for tuberculosis – meta-analysis Dec 2016 Tuberculosis not treated by 7,000 IU Vitamin D daily average for 6 weeks – RCT April 2015

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4769	TB and vitamin D.jpg		admin 28 Dec, 2014	25.47 Kb	1570
4716	TB 1.jpg		admin 12 Dec, 2014	24.08 Kb	1669
4715	TB Dec 2014.pdf	PDF 2014	admin 12 Dec, 2014	598.40 Kb	1248

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