Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis
BMC Pulmonary Medicine(2022) 22:39 https://doi.org/10.1186/s12890-022-01830-5
Yan Cao11, Xinjing Wang11, Ping Liu3t, Yue Su , Haotian Yu* and Jingli Du1*
Objective: Latent tuberculosis infection (LTBI) may be a risk of developing tuberculosis (TB) and thus a health hazard. The aim of this meta-analysis is to explore the association between vitamin D and LTBI.
Methods: Databases including PubMed, Embase, Scopus, and ProQuest were electronically searched to identify observational or interventional studies that reported the association between vitamin D and LTBI. The retrieval time is limited from inception to 30 September 2021. Two reviewers independently screened literature, extracted data, and assessed risk bias of included studies. Meta-analysis was performed by using STATA 12.0 software.
Results: A total of 5 studies involving 2 case-control studies and 3 cohort studies were included. The meta-analysis result showed that the risk of LTBI among individuals was not associated with high vitamin D level (OR 0.51,95% CI 0.05-5.65, P=0.58). The result from cohort studies also suggested that relatively high vitamin D level was not a protective factor for LTBI (RR = 0.56, 95%CI 0.19-1.67, P = 0.300).
Conclusions: Our meta-analysis suggested that serum vitamin D levels were not associated with incidence of LTBI, and relatively high serum vitamin D level was not a protective factor for LTBI. Further RCTs are needed to verify whether sufficient vitamin D levels and vitamin D supplementation reduces the risk of LTBI.
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VitamindWiki - Overview Tuberculosis and Vitamin D has
Many studies have found that Vitamin D both PREVENTS and TREATS TB
- As with many other diseases, we expect that there will be at least a 4X range of vitamin D due to:
- 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
- Poor Vitamin D Receptor activation results in far less vitamin D getting to cells
- However, a VDR restriction is not noticed by Vitamin D blood tests
- UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- TB 10X less likely to catch if have sufficient vitamin D – Dec 2011
- Trials using small vitamin D doses neither prevent nor treat TB 2023 2022 2020
- No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022
- Humans need a lot of Vitamin D as well
VitamindWiki -Tuberculosis meta-analyses
- Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
- Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis Sept 2021
- Tuberculosis still associated with low vitamin D – 12th meta-analysis June 2021
- Tuberculosis 3X more likely if less than 12 ng of Vitamin D - meta-analysis Sept 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
- Catching Tuberculosis from family member 2 X more likely if low vitamin D – meta-analysis Dec 2018
- Tuberculosis in children 1.7 X more likely if low vitamin D – meta-analysis Aug 2018
- Low vitamin D is a risk factor for tuberculosis – meta-analysis Dec 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- TB associated with low vitamin D in a review and meta-analysis – 2008
- TB and vitamin D updated review and meta-analysis – plays a role Jan 2010
Vitamin D Receptor gene reduces how much vitamin D gets to cells (TB in this case)
- TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
- TB and Leprosy are easily confused and associated with Vitamin D Receptor
- Certain types of Tuberculosis are 2X more likely with a poor Vitamin D Receptor – April 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
- TB risk in Blacks increased 20 percent having poor Vitamin D Receptors – Sept 2017
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
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