Expert Rev Respir Med. 2015 May 9:1-7. [Epub ahead of print]
Turnbull ER1, Drobniewski F.
Vitamin D plays a large role in the innate immune response against Mycobacterium tuberculosis (MTB) infection, activation and progression. Likewise, vitamin D deficiency is shown by evidence presented here to be a known risk factor for developing both MTB infection and active tuberculosis (TB). This comprehensive review discusses the evidence and remaining questions regarding vitamin D supplementation as a prophylactic measure in those who are at high risk of MTB infection and active TB. Vitamin D supplementation is routinely prescribed for osteoporosis prevention; yet, guidelines are lacking for its prescription for TB prevention, despite the adverse effects being rare. Policymakers are urged here to review the literature and provide urgent guidelines on vitamin D supplementation for TB prophylaxis.
The TOP articles are here:
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- Higher rates of TB in Winter and further from Equator – Nov 2012
- Vitamin D probably can prevent and treat TB and infectious diseases – 2012
- Multidrug-resistant tuberculosis may be reduced with vitamin D – Sept 2012
- TB treatment helped with Vitamin D – RCT Sept 2012