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TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT July 2020

Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease

Davaasambuu Ganmaa, Ph.D., Buyanjargal Uyanga, M.D., Xin Zhou, Ph.D., Garmaa Gantsetseg, M.D., Baigali Delgerekh, M.D., Davaasambuu Enkhmaa, Ph.D., Dorjnamjil Khulan, M.D., Saranjav Ariunzaya, M.D., Erdenebaatar Sumiya, B.Sc., Batbileg Bolortuya, M.D., Jutmaan Yanjmaa, Ph.D., Tserenkhuu Enkhtsetseg, M.D., et al.

Approx half of those getting vitamin D had <30 ng.
Only rarely does< 30 ng vitamin D help any health problem


TB and Intrvention:

TB and Meta-analysis:

 Download the PDF from VitaminDWiki

Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis. Data from phase 3, randomized, controlled trials of vitamin D supplementation to prevent tuberculosis infection are lacking.

We randomly assigned children who had negative results for M. tuberculosis infection according to the QuantiFERON-TB Gold In-Tube assay (QFT) to receive a weekly oral dose of either 14,000 IU of vitamin D3 or placebo for 3 years. The primary outcome was a positive QFT result at the 3-year follow-up, expressed as a proportion of children. Secondary outcomes included the serum 25-hydroxyvitamin D (25OHD) level at the end of the trial and the incidence of tuberculosis disease, acute respiratory infection, and adverse events.

A total of 8851 children underwent randomization: 4418 were assigned to the vitamin D group, and 4433 to the placebo group; 95.6% of children had a baseline serum 25(OH)D level of less than 20 ng per milliliter. Among children with a valid QFT result at the end of the trial, the percentage with a positive result was 3.6% (147 of 4074 children) in the vitamin D group and 3.3% (134 of 4043) in the placebo group (adjusted risk ratio, 1.10; 95% confidence interval CI, 0.87 to 1.38; P=0.42). The mean 25(OH)D level at the end of the trial was 31.0 ng per milliliter in the vitamin D group and 10.7 ng per milliliter in the placebo group (mean between-group difference, 20.3 ng per milliliter; 95% CI, 19.9 to 20.6). Tuberculosis disease was diagnosed in 21 children in the vitamin D group and in 25 children in the placebo group (adjusted risk ratio, 0.87; 95% CI, 0.49 to 1.55). A total of 29 children in the vitamin D group and 34 in the placebo group were hospitalized for treatment of acute respiratory infection (adjusted risk ratio, 0.86; 95% CI, 0.52 to 1.40). The incidence of adverse events did not differ significantly between the two groups.

Vitamin D supplementation did not result in a lower risk of tuberculosis infection, tuberculosis disease, or acute respiratory infection than placebo among vitamin D–deficient schoolchildren in Mongolia. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT02276755. opens in new tab.)

Created by admin. Last Modification: Sunday September 26, 2021 19:44:33 GMT-0000 by admin. (Version 6)

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