Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2 × 2 factorial design.
Food Funct. 2020 May 14. doi: 10.1039/c9fo02751c.
Wang J1, Xiong K1, Wang Q2, Zhao S3, Liu Y4, Ma A1.
400 IU of vitamin D is rarely enough to treat ANY health problem
Overview Tuberculosis and Vitamin D has the following summary
There are many indications that vitamin D both PREVENTS and TREATS TB
- As with many other diseases, VitaminDWiki expects that there will be a at least a 4X range of vitamin D due to:
- 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
- Also expect that co-factors and Vitamin D Receptor activators will prove to be very important
- UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
BACKGROUND AND OBJECTIVE:
Vitamin A and D have immunoregulatory effects and may improve the response to pulmonary tuberculosis treatment. The interaction of vitamin A and D on pulmonary tuberculosis treatment has not been studied. The objective is to investigate the effects of adjunctive supplementation of vitamin A, D and their interaction on the outcome of pulmonary tuberculosis treatment, primarily time to sputum smear conversion.
We conducted a randomized controlled trial with a 2 × 2 factorial design in Qingdao, China. Eight hundred patients were enrolled to receive standard pulmonary tuberculosis therapy alone (control), or together with vitamin A (2000 IU d-1), or vitamin D (400 IU d-1) or a combination of vitamin A (2000 IU d-1) and D (400 IU d-1) during the intensive-phase of pulmonary tuberculosis treatment.
761 patients were included in the tuberculosis symptom analysis; 521 patients with positive baseline sputum smear results were included in the sputum smear analysis. The allocation to vitamin A or D did not significantly influence the time to sputum smear conversion vitamin A: adjusted hazard ratio: 1.021, 95% CI: (0.821, 1.271); vitamin D: adjusted hazard ratio: 0.949, 95% CI: (0.760, 1.185). No significant interaction was observed between vitamin A and D supplementation (p = 0.660). Vitamin D supplementation significantly relieved the tuberculosis symptoms as indicated by decreased TBscore mean difference: -0.2, 95% CI: (-0.4, 0) in week 2 to 4.
Adjunctive supplementation of vitamin A and/or D did not improve the time to smear conversion in pulmonary tuberculosis patients. However vitamin D supplementation significantly improved tuberculosis symptoms during the first month of pulmonary tuberculosis treatment.
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