Vitamin D and malaria – many studies

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The role of Vitamin D in malaria – Jan 2015

J Infect Dev Ctries. 2015 Jan 15;9(1):8-19. doi: 10.3855/jidc.3687.
Khanh Vinh Quốc Luong, Lan Thi Hoàng Nguyen
Vietnamese American Medical Research Foundation, Westminster, California, United States. lng2687765 at aol.com.

An abnormal calcium-parathyroid hormone (PTH)-vitamin D axis has been reported in patients with malaria infection. A role for vitamin D in malaria has been suggested by many studies. Genetic studies have identified numerous factors that link vitamin D to malaria, including human leukocyte antigen genes, toll-like receptors, heme oxygenase-1, angiopoietin-2, cytotoxic T lymphocyte antigen-4, nucleotide-binding oligomerization domain-like receptors, and Bcl-2. Vitamin D has also been implicated in malaria via its effects on the Bacillus Calmette-Guerin (BCG) vaccine, matrix metalloproteinases, mitogen-activated protein kinase pathways, prostaglandins, reactive oxidative species, and nitric oxide synthase.

Vitamin D may be important in malaria; therefore, additional research on its role in malaria is needed.

Conclusions (Clipped from PDF)

In this paper, the relationship between vitamin D and malaria was reviewed. Genetic studies provide opportunities to determine which proteins link vitamin D to malaria pathology. Vitamin D is able to act through numerous non-genomic mechanisms, including protein expression, oxidative stress, inflammation, and cellular metabolism. Therefore, further research on the role of vitamin D in malaria is needed, and a cautious approach is advisable before recommending the widespread use of vitamin D for malaria.
 Download the PDF from VitaminDWiki.

10 papers cited this study as of Dec 2021

Effects of Vitamins in Augmentation of Malaria Treatment: A review - 2016
A, B, C, D, E  Download the PDF from VitaminDWiki

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VitaminDWiki pages with MALARIA in title (9 as of April 2022)

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Search Google Scholar for Malaria "vitamin d": 23,900 studies as of April 2022

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• Relative Burdens of the COVID-19, Malaria, Tuberculosis, and HIV/AIDS Epidemics in Sub-Saharan Africa
  • Dec 2021 see VitaminDWiki HIV, TB, Malaria more important than COVID to lower Africa - Dec 2021
• Pediatric Cerebral Malaria - Jan 2021 https://doi.org/10.1007/s40475-021-00227-4
• Oral administration of vitamin D and importance in prevention of cerebral malaria - Nov 2018 PDF
  • All mice given Vitamin D survived, all mice without Vitamin d died
  • 

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