Loading...
 

Vitamin D and malaria – many studies


Does malaria have any association with vitamin D - Perplexity AI Deep Research May 2025

In a 2014 study of Ugandan children, researchers found that 95% of children with severe malaria and 80% of control children were vitamin D-insufficient (plasma 25(OH)D <30 ng/mL).
Mean plasma vitamin D levels were significantly lower in children with severe malaria than in community children (21.2 vs. 25.3 ng/mL, p = 0.03).
These findings led researchers to conclude that

for every 1 ng/mL increase in plasma vitamin D, the odds of having severe malaria declined by 9%__

[OR = 0.91 (95% CI: 0.84, 1.0)]
 Download the PDF from VitaminDWiki


10+ VitaminDWiki pages with MALARIA in the title

This list is automatically updated

Items found: 10

2022 Deaths:TB = 1.3 million, Malaria = 0.6 million


10% to 20% more likely for under- five children to get malaria within 6 months of low vitamin D test - Dec 2023

Vitamin D status and the risk of malaria among under-five children in Africa - Dec 2023 abstract only

Background Vitamin D deficiency (VDD) and malaria are conditions of public health importance whose burden is still rising among children globally and in sub-Saharan Africa (SSA). Animal studies have found evidence of the association between VDD and various outcomes, including malaria. However, few observational studies quantifying the effect of VDD or vitamin D insufficiency (VDI) on malaria in humans exist. This study aimed to examine the effect of vitamin D on malaria risk among children in SSA.

Methods This analysis utilised data from a prospective birth cohort in Entebbe, Uganda and a community-based cohort in Kilifi, Kenya. Univariate and multivariable Poisson regression with robust standard errors, logistic, and linear regression models were used to estimate the effect of vitamin D on malaria (incidence/risk/antibodies), respectively.

Results Of the 2493 children analysed, 42.0% had VDD/VDI (25(OH)D levels<75nmol/L). After adjusting for age, sex, iron deficiency (ID) and country, there was some evidence of an association between VDD/VDI and malaria incidence at 6 months following vitamin D measurement (ARR:1.18;95%CI:0.98–1.42;p=0.072). Malaria risk and incidence results were similar. After adjusting for age, sex, ID, inflammation, and cohort, there was strong evidence of an association between VDD/VDI and higher log anti-AMA-1 (Adjusted β:0.25;95%CI:0.08,0.43;p-value=0.004). Some differences in the relationship between VDD/VDI and malaria antibody levels were seen between cohorts.

Conclusion Low vitamin D levels are associated with increased malaria incidence and P.falciparum antibodies. The results of this analysis were consistent with the evidence from animal studies and did not support the clues found in some existing observational studies. These results suggest that VDD/VDI may play a role in advancing malaria infection, but the malaria antibody results could be due to reverse causality. Further research is warranted to confirm the malaria incidence/risk results and address the direction of causality between VDD/VDI and malaria antibodies using Mendelian randomisation.


Search Google Scholar for Malaria "vitamin d": 28,200 studies as of May, 2025

Query Google Scholar



There have been 10475 visits to this page

 


Created by admin. Last Modification: Monday May 19, 2025 10:48:50 GMT-0000 by admin. (Version 31)

Attached files

ID Name Comment Uploaded Size Downloads
22625 The Association Between Malaria and Vitamin D_ Evi.pdf admin 19 May, 2025 264.84 Kb 2
20511 Malaria mice meta_CompressPdf.pdf admin 22 Dec, 2023 377.24 Kb 95
17408 prevention of cerebral malaria.pdf admin 14 Apr, 2022 1.67 Mb 169
17407 Malaria Mice.jpg admin 14 Apr, 2022 24.89 Kb 289
10585 6-Effects-of-Vitamins-in-Augmentation-of-Malaria-Treatment-A-review.pdf admin 23 Sep, 2018 491.78 Kb 660
4921 The role of Vitamin D in malaria.pdf admin 18 Jan, 2015 516.43 Kb 966