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Poor Tuberculosis outcomes if low vitamin D and diabetic – Dec 2019

Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a program setting in China

Tropical Medicine and International Health https://doi.org/10.1111/tmi.13355
Yan Lin Yunlong Bai Tiejuan Zhang Wanli Kang Demei Kang Qiang Miao Yunlong Wang Hongshan Shao Xiangwen Li Grania Brigden … See all authors

VitaminDWiki

Note: Diabetis is associated with low vitamin D

Patients having both Diabetes and TB treated by vitamin D – June 2012

Overview Tuberculosis and Vitamin D has the following summary

There are many indications that vitamin D both PREVENTS and TREATS TB

  • As with many other diseases, VitaminDWiki expects that there will be a at least a 4X range of vitamin D due to:
    • 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
  • Also expect that co-factors and Vitamin D Receptor activators will prove to be very important
  • UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
TB and vitamin D 106 items

Items in both categories TB and Radomized Controlled Trials are listed here:


Items in both categories TB and Meta-analysis are listed here:


Objective
Tuberculosis (TB) treatment success rates are high in China, but there are still a considerable number of cases who have unfavourable treatment outcomes (UTO). We aimed to determine the pro‐portion of TB patients with UTO and to assess whether baseline characteristics that included glycaemic status [normal fasting blood glucose (FBG), transient hyperglycaemia and diabetes mellitus (DM)] and vitamin D status were associated with UTO.

Method
Prospective cohort study conducted between November 2015 and July 2016 at six clinics within routine TB services in Jilin province, where persons with TB were consecutively recruited. Data analysis was performed using the chi square test and multivariate logistic regression.

Results
Of 306 recruited TB patients, 96 (31.4%) had smear positive pulmonary TB, 187 (61.1%) had smear‐negative pulmonary TB and 23 (7.5%) had extra pulmonary TB (EPTB). Of these, 95 (31.1%) had normal blood glucose, 83 (27.1%) had transient hyperglycaemia and 128 (41.8%) had DM. 227 (74.2%) patients had vitamin D deficiency/severe deficiency. There were 125 (40.8%) patients with UTO of whom the majority were lost to follow‐up (57.6%) or not evaluated (28.8%). UTO was significantly associated with smear negative pulmonary TB (P=0.009), EPTB (P<0.001), and DM (P=0.007).

Conclusion
The proportion of TB patients with UTO increased with smear‐negative pulmonary TB, EPTB and DM. TB Programmes need to pay more attention to these issues and ensure intensive patient support to those at risk and early detection of DM.


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