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TB not helped by Vitamin D (did not even measure Vit D levels) – June 2019

Vitamin D as an Adjunctive Treatment to Standard Drugs in Pulmonary Tuberculosis Patients: An Evidence-Based Case Report

Advances in Preventive Medicine, Volume 2019, https://doi.org/10.1155/2019/5181847
Diajeng Ayesha Soeharto,1 Diana Ashilah Rifai,1 Stella Marsudidjadja,1 Aisha Emilirosy Roekman,1 Chadijah Karima Assegaf,1 and Melva Louisa2

  1. Majority of the trials lasted only 8 weeks, which is not long enough for Vitamin D levels to plateau
  2. Standard vitamin D is known to have a poor response in those with poor guts
  3. Perhaps TB drugs decrease Vitamin D response

Overview Tuberculosis and Vitamin D has the following summary
There are many indications that vitamin D both PREVENTS and TREATS TB

  • As with many other diseases, we expect that there will be at least a 4X range of vitamin D due to:
    • 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
  • Also expect that co-factors and Vitamin D Receptor activators will prove to be very important
  • UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
TB and vitamin D 112 items

Items in both categories TB and Radomized Controlled Trials are listed here:

Items in both categories TB and Meta-analysis are listed here:

 Download the PDF from Sci-Hub via VitaminDWiki

Background. Vitamin D has a prominent role in the body’s innate immunity as it is important in the maintenance of macrophages and monocytes and its function in defending against infections. In-vitro studies have established vitamin D’s potential role in tuberculosis (TB) infection, in that it restricts Mycobacterium tuberculosis growth, thus implying the potential benefit of vitamin D as an adjunctive treatment for TB. However, clinical trials and reviews have contradicting findings regarding the true clinical efficacy of adjunctive vitamin D, particularly in reducing the sputum conversion rate (SCR).

Objective. This study aims to update the current evidence regarding vitamin D supplementation as an adjunctive treatment in achieving the smear sputum conversion rate (SCR) among pulmonary TB patients.

Method. A comprehensive search was conducted in October 2018 in PubMed-NCBI, MEDLINE-OVID, SCOPUS-Elsevier, and Cochrane. The selection of studies was done as per the predetermined inclusion and exclusion criteria of this EBCR and resulted in the inclusion of 11 eligible studies (8 RCTs and 3 systematic reviews). The selected studies were then critically appraised for their validity, importance, and applicability according to the CEBM (Centre for Evidence-Based Medicine) appraisal tools.

Results. Overall, most of the trials showed no statistically significant changes in terms of the proportion of TB patients with a negative sputum smear conversion in the group treated with an adjunctive therapy vs. the group treated with standard antituberculosis therapy alone. Only one trial showed significant results, which was conducted in a population of TB patients with vitamin D deficiency. Furthermore, overall the reviews showed no significant change in the 8-week sputum smear conversion after treatment within the group given vitamin D in comparison to those who were not.

Conclusion. Vitamin D as adjunctive therapy in TB patients shows no clinical improvement in terms of sputum conversion to antituberculosis management.

Created by admin. Last Modification: Thursday June 20, 2019 16:04:47 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
12171 TB and Vitamin D.pdf PDF 2019 admin 20 Jun, 2019 15:49 1.51 Mb 311
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