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Tuberculosis not prevented by a tiny amount of vitamin D (equiv to 1,400 IU daily) – RCT May 2023


Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicentre phase 3 double-blind randomised placebo-controlled trial (ViDiKids)

Int J Infect Dis. 2023 May 19;S1201-9712(23)00562-3. doi: 10.1016/j.ijid.2023.05.010
Keren Middelkoop 1, Justine Stewart 1, Neil Walker 2, Carmen Delport 3, David A Jolliffe 4, Anna K Coussens 5, James Nuttall 6, Jonathan C Y Tang 7, William D Fraser 7, Christopher J Griffiths 2, Geeta Trilok Kumar 8, Suzanne Filteau 9, Richard L Hooper 2, Robert J Wilkinson 10, Linda-Gail Bekker 3, Adrian R Martineau 11

Background: Vitamin D metabolites induce innate antimycobacterial responses in vitro. Observational studies consistently report independent associations between vitamin D deficiency and increased susceptibility to Mycobacterium tuberculosis infection.

Methods: We conducted a randomised placebo-controlled trial to determine whether weekly oral supplementation with 10,000 IU vitamin D3 for 3 years reduced risk of sensitisation to M. tuberculosis in Cape Town schoolchildren aged 6-11 years with negative QuantiFERON-TB Gold Plus (QFT-Plus) assay results at baseline. The primary outcome was a positive end-trial QFT-Plus result, analysed using a mixed effects logistic regression model with school of attendance included as a random effect.

Results: 1682 children attending 23 schools were randomised (829 to vitamin D, 853 to placebo). Mean end-study 25(OH)D concentrations in participants randomised to vitamin D vs. placebo were 104.3 vs. 64.7 nmol/L, respectively (95% CI for difference, 37.6 to 41.9 nmol/L). 76/667 (11.4%) participants allocated to vitamin D vs. 89/687 (13.0%) participants allocated to placebo tested QFT-Plus positive at 3-year follow-up (adjusted odds ratio 0.86, 95% CI 0.62 to 1.19, P=0.35).

Conclusions: Weekly oral supplementation with 10,000 IU vitamin D3 for 3 years elevated serum 25(OH)D concentrations among Cape Town schoolchildren but did not reduce their risk of QFT-Plus conversion.
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14 studies of TB and Vitamin D Intervention

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VitaminDwiki – Tuberculosis category contains

121 Tuberculosis studies:    14 RCT,   14 Meta-analyses,  8 Vitamin D Receptor

see also Overview Tuberculosis and Vitamin D    Breathing category
TB has been increasing
TB global incidence


VitaminDwiki – Overview Tuberculosis and Vitamin D contains

Many studies have found that Vitamin D both PREVENTS and TREATS TB

TB and vitamin D 121 items

Attached files

ID Name Comment Uploaded Size Downloads
19580 TB 10,000 IU_CompressPdf.pdf admin 22 May, 2023 408.66 Kb 73