Randomized Study of the Effects of Vitamin D and Magnesium Co-Supplementation on Muscle Strength and Function, Body Composition, and Inflammation in Vitamin D-Deficient Middle-Aged Women - Sept 2020
Biological Trace Element Research volume 199, pages 2523–2534 (2021
Fatemeh Kheyruri, Javad Sarrafzadeh, Agha Fatemeh Hosseini, Behnaz Abiri & Mohammadreza Vafa
This study aimed to investigate the effects of vitamin D and magnesium co-supplementation on muscle strength and function, body composition, and inflammation in vitamin D-deficient middle-aged women. In this study, 83 healthy middle-aged women (40–55 years) with vitamin D deficiency were randomly assigned into two groups: (1) intervention: receiving a 50,000-IU vitamin D soft gel (weekly) plus a 250-mg magnesium tablet (daily); (2) control: receiving a vitamin D placebo (weekly) plus a magnesium placebo (daily), for 8 weeks. Before and after the intervention, anthropometric indices, muscle strength, muscle function, and some inflammatory markers were measured. After 8 weeks of supplementation, significant difference was observed in handgrip strength and time for Time Get Up and Go (TGUG) test between the intervention and placebo groups (P < 0.05). Regarding percentage of fat mass (FM%) and fat free mass (FFM%), and knee extension strength, there was no significant difference between the two groups at the end of intervention (P > .05). Serum 25(OH)-D levels increased significantly (P < 0.001) and its change was significantly different between the two groups, at the end of the intervention (P < 0.001). Serum level of hs-CRP decreased significantly in the intervention group compared to baseline (P < 0.001), and the change in hs-CRP was significant between the two groups at the end of the intervention (P < 0.01). Furthermore, serum level of TNF-α declined significantly in the intervention group compared to baseline (P < 0.001) but, no significant differences were seen between the two groups in regard of serum levels of TNF-α and IL-6 after the intervention (P > 0.05).
Our findings show that vitamin D and magnesium co-supplementation, for 8 weeks, in healthy middle-aged women with vitamin D deficiency have beneficial impacts on muscle strength, muscle function, and probably inflammation.
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Muscle improvement RCT with 50,000 IU of Vitamin D (no Magnesium) - Aug 2019
Muscle strength and quality of life improved after vitamin D supplementation among adult Saudi females
Clinical Nutrition Experimental Vol 26, August 2019, Pages 34-43 https://doi.org/10.1016/j.yclnex.2019.04.002
Mohammed Ewid a b, Mohammed AlTelbany c, Syed Muhammad Baqui Billah a, Nazmus Saquib a, Akram Helmy d, Saadi AlJundi a, Tawfik Rajab a, Saed Enabi a, Ahmed AlShwaikh a, Abdullah Morhaf a, Hossam Sherif a e
Background & aims
Physical and mental well-being following vitamin D supplementation shows contradictory data in the literature. We aimed to explore this more among young and middle-aged Saudi females suffering from vitamin D deficiency by analyzing handgrip strength and self-reported quality of life.
Methods
Fifty-eight females with bone or muscle aches attending the outpatient orthopedics clinic of an area hospital were enrolled after informed consent. Each participant filled out the SF-8™ questionnaire for quality of life (QOL) and was assessed for demographic/behavioral data, serum level of 25-hydroxyvitamin D (25(OH)D), and handgrip (HG) for both hands at baseline and 3 months after standard 25(OH)D oral supplementation.
Results
The mean age was 31.9 ± 7.3 years; serum 25(OH)D values increased significantly after the oral supplementation (11.28 ± 4.1, range 4.2–22 vs. 23.98 ± 6.81, range 7–41.4 μg/dl, P < 0.001) The handgrip mean for both hands after 25(OH)D supplementation also showed statistically significant higher values (13.24 ± 4.95, range 5–25.33 vs. 17.76 ± 4.39, range 9.5–27.33 kg/m2, P < 0.001). The SF-8™ QOL questionnaire results showed an overall statistically significant improvement (P < 0.001). 25(OH)D baseline values predicted muscle weakness; area-under-the-curve was 63% (95% CI: 47–79%) with the best cut-off value at 17.17 μg/dl (sensitivity 64% and specificity 62%).
Conclusion
Adult Saudi females showed improved muscle strength and quality of life following standard 25(OH)D oral supplementation.
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147+ VitaminDWiki pages with MUSCLE, etc in the title
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Items found: 148
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Protein increases weight loss and muscle growth - May 2025 |
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21 May, 2025 |
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Does Vitamin D Mimic the Effect of Anabolic Steroids - April 2025 |
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26 Apr, 2025 |
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Little increase in muscles by adding exercise, protein and Vitamin D for 10 days (no surprise) - Feb 2025 |
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24 Apr, 2025 |
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Young adults eating Ultraprocessed Foods 60% more likely to have lower Muscle Mass (Vitamin D can help) - Feb 2025 |
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13 Feb, 2025 |
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Protein, muscles, bones and Vitamin D - many studies |
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16 Dec, 2024 |
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Protein helps muscles, sarcopenia, metabolism, diabetes (Patrick) is aided by Vitamin D - Dec 2024 |
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05 Dec, 2024 |
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40% of weight loss from GLP-1 is from muscle loss (not so if lose weight with Vitamin D) - Nov 2024 |
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22 Nov, 2024 |
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40% of weight loss from GLP-1 is from muscle loss, not fat loss (including heart muscle) - Nov 2024 |
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22 Nov, 2024 |
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Magnesium helps muscles in more than 10 ways - Dec 2023 |
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18 Oct, 2024 |
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Muscles and Vitamin D - many studies |
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13 Aug, 2024 |
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Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 |
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23 May, 2024 |
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Muscle strength improved with Calfidediol (a form of vitamin D) - meta-analysis May 2022 |
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29 Feb, 2024 |
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Muscle Inflammation (idiopathic inflammatory myopathy) 3.2 X more likely if low Vitamin D – meta-analysis Feb 2024 |
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29 Feb, 2024 |
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Handgrip and Vitamin D - many studies |
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20 Feb, 2024 |
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Female preemies become women with low hand grip strength - Dec 2023 |
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24 Dec, 2023 |
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Omega-3 helps muscles - many studies |
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16 Nov, 2023 |
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Fatigue reduced by Vitamin D (Cancer, muscle, MS, age, etc) - many studies |
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12 Nov, 2023 |
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Skeletal Muscles regenerated with Vitamin D supplementation – review Oct 2023 |
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29 Oct, 2023 |
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Pelvic Organ Prolapse after menopause 5.6 X more likely if low Vitamin D (weak muscles) – Oct 2023 |
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02 Oct, 2023 |
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Muscles improved in women with 50,000 IU vitamin D weekly (8 weeks) plus daily Magnesium – RCT Sept 2020 |
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16 Sep, 2023 |
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Muscle pain in obese women reduced by aerobic exercise plus 50,000 IU Vitamin D - RCT May 2021 |
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27 Aug, 2023 |
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Sarcopenia (muscle loss) is reduced by vitamin D and many other supplements - July 2023 |
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27 Aug, 2023 |
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Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 |
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20 Aug, 2023 |
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Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies |
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11 Jul, 2023 |
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Some excess calories diverted to muscle growth if high level vitamin D (exercising mice) – preprint May 2022 |
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02 Jun, 2023 |
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Muscular Dystrophy probably treated by high-dose Vitamin D plus muscle rehab |
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23 Mar, 2023 |
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Off topic: back muscle pain quickly treated by TENS - Jan 2023 |
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25 Jan, 2023 |
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More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 |
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26 Nov, 2022 |
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Grip strength of children not improved by 800 IU Vitamin D daily (not nearly enough) – RCT Feb 2018 |
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31 Oct, 2022 |
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Exercise-induced muscle damage fought when enough vitamin D used for long enough – review Sept 2022 |
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24 Sep, 2022 |
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Frailty and low muscle mass both associated with low vitamin D – Aug 2013 |
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14 Sep, 2022 |
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Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 |
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30 Jun, 2022 |
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Omega-3 improves elderly muscles – 2 meta-analyses |
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06 Jun, 2022 |
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High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022 |
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20 May, 2022 |
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3X less muscle atrophy after ACL surgery if more than 40 ng of vitamin D – May 2022 |
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14 May, 2022 |
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Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022 |
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09 Apr, 2022 |
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Handgrip strength increased 9 percent in college athletes with 8 weeks of Omega-3 – RCT Feb 2022 |
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18 Mar, 2022 |
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Muscle Strength improved 1.4 to 19 percent by vitamin D3 (not D2) – systematic review June 2016 |
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13 Feb, 2022 |
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Role of Vitamin K in Bones and Muscles - Feb 2022 |
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13 Feb, 2022 |
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Some vitamin D is stored in skeletal muscles – multiple studies |
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27 Dec, 2021 |
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Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 |
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16 Oct, 2021 |
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Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 |
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16 Oct, 2021 |
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Less muscle inflammation after exercise if high level of Vitamin D (50 ng) -July 2021 |
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08 Jul, 2021 |
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Low muscle strength predicts low vitamin D level in elderly – March 2021 |
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06 May, 2021 |
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Adding just a little vitamin D does not help (muscle mass in this case) – meta-analysis Jan 2021 |
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06 Feb, 2021 |
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Low muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – Dec 2020 |
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04 Jan, 2021 |
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4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT Jan 2020 |
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21 Sep, 2020 |
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Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 |
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23 Jul, 2020 |
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Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020 |
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30 Jan, 2020 |
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2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014 |
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23 Dec, 2019 |
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Muscles not improved by just Vitamin D weekly (also need exercise) – Dec 2019 |
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17 Dec, 2019 |
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Low vitamin D resulted in reduced genes to make muscles (in rats) – Nov 2019 |
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11 Nov, 2019 |
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Active muscles store vitamin D in the winter - Oct 2019 |
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11 Oct, 2019 |
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Omega-3 helps muscles – Aug 2019 |
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24 Aug, 2019 |
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Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019 |
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10 Aug, 2019 |
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8 Signs of Low Vitamin D - sweating, bones ache, muscle pain, poor immune, fatigue, slow healing etc. – YouTube Dec 2018 |
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05 Aug, 2019 |
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Vitamin D stored in muscle via Vitamin D Binding Protein – July 2019 |
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30 Jul, 2019 |
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Mechanisms of vitamin D action in skeletal muscle – June 2019 |
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22 Jun, 2019 |
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Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 |
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09 May, 2019 |
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Vitamin D supplementation increases strength of lower muscles – Meta-analysis April 2019 |
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01 May, 2019 |
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Vitamin D does not help gain muscle mass (when only use small doses) – March 2019 |
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03 Mar, 2019 |
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Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 |
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23 Feb, 2019 |
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Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019 |
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12 Feb, 2019 |
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Protein aids muscle gain – meta-analysis March 2018 |
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02 Jan, 2019 |
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Vitamin D and muscle – April 2019 |
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07 Dec, 2018 |
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Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018 |
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14 Sep, 2018 |
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Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 |
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21 Aug, 2018 |
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Dietary Protein, Muscle and Physical Function in the Very Old – July 2018 |
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17 Aug, 2018 |
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Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018 |
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06 Aug, 2018 |
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Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018 |
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14 Jul, 2018 |
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Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 |
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13 Jul, 2018 |
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Muscle problems are both treated and avoided by Vitamin D – April 2018 |
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03 Jul, 2018 |
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Seniors getting Vitamin D (but no exercise) for 3 months failed to increase muscle strength – RCT June 2018 |
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03 Jul, 2018 |
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Muscle, etc. problems if consume little vitamin D (mice) – June 2018 |
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27 Jun, 2018 |
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Poor handgrip strength in 5-year-old girls 3X more likely if low vitamin D – May 2018 |
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24 May, 2018 |
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Vitamin D weekly supplementation (Spinal Cord Injury athletes) increased handgrip strength – May 2018 |
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15 May, 2018 |
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Muscle pain (Low Magnesium) plus Low Vitamin D associated with 10X more Cancer, etc (San Francisco) – Aug 2017 |
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13 Apr, 2018 |
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Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018 |
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08 Apr, 2018 |
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Fewer Breast Cancer deaths if more muscle (probably due to less fat, more Vitamin D) – April 2018 |
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07 Apr, 2018 |
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Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015 |
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03 Mar, 2018 |
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Osteoporosis and low grip strength both associated with low vitamin D – Feb 2018 |
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13 Feb, 2018 |
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Headaches (chronic tension) 3X more likely to have low vitamin D – also muscle weakness and bone tenderness – May 2017 |
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25 Jan, 2018 |
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Weaker hand grip if poor Vitamin D Receptor (15 percent) – Nov 2016 |
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12 Nov, 2017 |
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Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017 |
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29 Aug, 2017 |
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Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015 |
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27 Jul, 2017 |
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Muscle strength not increased by Vitamin D - 96 percent were not deficient – RCT April 2017 |
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20 Jul, 2017 |
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Infant muscle development best with 400 IU of vitamin D (not 800) – Sept 2015 |
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13 Jul, 2017 |
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Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016 |
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08 Jun, 2017 |
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Muscle strength not increased by Vitamin D when 96 percent already had enough – RCT April 2017 |
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30 Apr, 2017 |
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Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 |
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08 Mar, 2017 |
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More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017 |
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02 Mar, 2017 |
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Handgrip strength dropped by 20 percent in the last generation (perhaps due to lower vitamin D) - Feb 2017 |
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02 Mar, 2017 |
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Severely burned children recovered muscle capability much faster with daily 1000 IU of vitamin D – RCT March 2017 |
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01 Mar, 2017 |
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Hypothesis: Less severe muscle damage if vitamin D level had been normalized – July 2013 |
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21 Feb, 2017 |
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Large single-dose of Omega-3 reduced expected muscle damage – Feb 2017 |
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21 Feb, 2017 |
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Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 |
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31 Jan, 2017 |
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Sarcopenic added 1 lb of muscle in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 |
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31 Jan, 2017 |
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Osteosarcopenic obesity (obese with low bone and muscle mass) twice as likely if low vitamin D – Oct 2016 |
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31 Jan, 2017 |
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More muscle torque associated with higher vitamin D – Jan 2017 |
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05 Jan, 2017 |
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Vitamin D increased muscle strength by 1% to 19% (varied with dose and duration) – review June 2016 |
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22 Nov, 2016 |
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Vitamin D increased muscle strength by 1 to 19 percent – review June 2016 |
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22 Nov, 2016 |
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Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 |
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22 Nov, 2016 |
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Myotonic dystrophy a (rare genetic muscle problem) associated with low vitamin D – Nov 2016 |
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18 Nov, 2016 |
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Myotonic dystrophy (a rare genetic muscle problem) associated with low vitamin D – Nov 2016 |
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18 Nov, 2016 |
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Muscle strength is associated with vitamin D receptor gene variants – March 2016 |
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12 Nov, 2016 |
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Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015 |
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31 Oct, 2016 |
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Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 |
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31 Oct, 2016 |
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Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016 |
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06 May, 2016 |
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Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011 |
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05 May, 2016 |
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Sunshine is a cure for “weak and soft muscles” – 425 BC |
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22 Apr, 2016 |
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Senior muscles increased somewhat with Omega-3 – RCT July 2015 |
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18 Jan, 2016 |
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Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015 |
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05 Nov, 2015 |
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More muscle response when have adequate vitamin D |
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27 Jul, 2015 |
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Pelvic floor muscle strength is low after giving birth if vitamin D deficient – March 2015 |
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20 Mar, 2015 |
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Weight loss includes muscle loss unless add vitamin D, whey and leucine – RCT Feb 2015 |
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07 Feb, 2015 |
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Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014 |
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27 Jan, 2015 |
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Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013 |
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27 Jan, 2015 |
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Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013 |
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27 Jan, 2015 |
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Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013 |
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27 Jan, 2015 |
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People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014 |
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20 Dec, 2014 |
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Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014 |
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18 Jul, 2014 |
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Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013 |
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05 May, 2014 |
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MRI of elderly skeletal muscle lacking vitamin D – April 2014 |
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30 Apr, 2014 |
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Muscle cells differentiate into fat cells if there is low vitamin D in petrie dish – April 2013 |
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30 Apr, 2014 |
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Skeletal muscles helped by vitamin D – Review Feb 2014 |
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08 Feb, 2014 |
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Higher vitamin D during pregnancy associated with stronger hand grip at age 4 – Oct 2013 |
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03 Jan, 2014 |
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Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 |
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23 Dec, 2013 |
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Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 |
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19 Dec, 2013 |
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Muscle strength not increased by raising vitamin D to only 30 ng – RCT Aug 2012 |
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19 Dec, 2013 |
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Vitamin D provides faster recovery after muscle overuse – April 2013 |
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18 Dec, 2013 |
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Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012 |
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23 Oct, 2013 |
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Evidence that vitamin D is also stored in muscle cells – Sept 2013 |
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26 Sep, 2013 |
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Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 |
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10 Aug, 2013 |
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Hypothesis: Low vitamin D is one of the causes of muscle weakness in alcoholics – Dec 2012 |
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31 Jul, 2013 |
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More muscle injuries in NFL players who were low on vitamin D – July 2011 |
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13 Jul, 2013 |
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Muscle inflammation 17X more probable if vitamin D deficient – Feb 2013 |
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13 Jul, 2013 |
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Muscle improved by increasing vitamin D if previously less than 24 ng – June 2013 |
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02 Jul, 2013 |
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Most immigrant women in Sweden had little vitamin D and lots of muscle pain – May 2013 |
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22 May, 2013 |
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Deadly amount of vitamin D speeds up recovery of crushed muscles in rats – Dec 2012 |
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19 Apr, 2013 |
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Relevance of Vitamin D in Bone and Muscle Health of Cancer Patients - Jan 2013 |
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06 Dec, 2012 |
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Vitamin D2 intervention increased elderly muscle strength – Nov 2010 |
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10 Nov, 2012 |
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Higher vitamin D helps regain muscle strength after knee surgery – July 2011 |
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01 Sep, 2011 |
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Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010 |
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14 Sep, 2010 |
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Skeletal Muscle weakness from lack of vitamin D fixed by adding Calcium and phosphorus – Aug 2010 |
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11 Aug, 2010 |
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Vitamin D, Muscle Function, and Exercise Performance in kids – June 2010 |
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09 Jun, 2010 |
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Vitamin D improving muscles may be due to improving phosphate levels – June 2010 |
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03 Jun, 2010 |
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Vit D associated with less muscle fat |
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11 Apr, 2010 |
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Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019 |
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No value for 'modification_date_major' |