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Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018

The association between vitamin D concentration and pain: a systematic review and meta-analysis.

Public Health Nutr. 2018 Mar 21:1-16. doi: 10.1017/S1368980018000551. Epub ahead of print
Wu Z1, Malihi Z1, Stewart AW1, Lawes CM1, Scragg R1.


Strangely, the study lists two other sets of pain trials, but did not analyze them
Chronic lower back

Pain - chronic category has the following

161 items in category Chronic pain

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The PDF was available on Sci-Hub.tw as of April 2018

Pain-related conditions, such as chronic widespread pain and fibromyalgia, are major burdens for individuals and the health system. Evidence from previous research on the association between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and pain is conflicting. Thus, we aimed to determine if there is an association between mean 25(OH)D concentration (primary aim), or proportion of hypovitaminosis D (secondary aim), and pain conditions in observational studies.

Published observational research on 25(OH)D concentration and pain-related conditions was systematically searched for in electronic sources (MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials) and a random-effects meta-analysis was conducted on included studies.

Eighty-one observational studies with a total of 50 834 participants were identified. Compared with controls, mean 25(OH)D concentration was significantly lower in patients with

  • arthritis (mean difference (MD): -12·34 nmol/l; P<0·001),
  • muscle pain (MD: -8·97 nmol/l; P=0·003) and
  • chronic widespread pain (MD: -7·77 nmol/l; P<0·001),

but not in patients with headache or migraine (MD: -2·53 nmol/l; P=0·06).
The odds of vitamin D deficiency was increased for arthritis, muscle pain and chronic widespread pain, but not for headache or migraine, compared with controls. Sensitivity analyses revealed similar results.

A significantly lower 25(OH)D concentration was observed in patients with arthritis, muscle pain and chronic widespread pain, compared with those without. These results suggest that low 25(OH)D concentrations may be associated with pain conditions.

PMID: 29559013 DOI: 10.1017/S1368980018000551

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