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Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016

Vitamin D supplementation trial in infancy: body composition effects at 3 years of age in a prospective follow-up study from Montréal

T. J. Hazell1, S. Gallo2, C. A. Vanstone3, S. Agellon3, C. Rodd4 andH. A. Weiler3,
Pediatric Obesity, Article first published online: 4 FEB 2016. DOI: 10.1111/ijpo.12105

Background: The impact of vitamin D status on body composition is not well understood.

Objectives: Evaluate how vitamin D supplementation in infancy affects body composition at 3 years of age.

Methods: Double-blind randomized trial of 132, 1-month-old healthy, breastfed infants randomly assigned to receive oral vitamin D3 supplements of 400, 800, 1200 or 1600 IU d−1 for 11 months. In the present analysis, 87 (66%) returned at 3 years of age. Body composition was measured using dual-energy x-ray absorptiometry and plasma 25-hydroxyvitamin D [25(OH)D] concentrations by liquid chromatography tandem mass spectrometry.

Results: Anthropometry, body composition, diet, activity and demographics were similar across dosage groups at 3 years. Mean 25(OH)D concentration from 1 month to 3 years was higher (P < 0.001) in the 1200 IU group than 800 and 400 IU groups. Children with 25(OH)D concentrations above 75 nmol L−1 had lower fat mass (~450 g; P = 0.049). In multiple linear regression, mean 25(OH)D was associated with lean mass percent (β = 0.06; CI: 0.00, 0.12; P = 0.042), fat mass (β = −11.29; CI: −22.06, −0.52; P = 0.048) and body fat percent (β = −0.06; CI: −0.12, −0.01; P = 0.045).

Conclusions
Higher vitamin D status from infancy through to 3 years of age associates with leaner body composition.

 Download the PDF from VitaminDWiki


VitaminDWiki
  • Nice results
  • Would have had far better results if they had varied the vitamin D dose size with weight
    100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
  • Also would have had better results if had continued the vitamin D supplementation from age 1 to age 3

From the PDF: 1600 IU tallest, most active, leanest

Response to constant amount of vitamin D

Image
1600 IU is too much at 1 month but too little at 12 months
Dose should not be constant, but be proportional to weight


See also VitaminDWiki

Intervention AND Infant/Child

Infant-Child category starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

  • Sun is great – well known for 1,000’s of years.
    US govt (1934) even said infants should be out in the sun
  • One country recommended 2,000 IU daily for decades – with no known problems
  • As with adults, infants and children can have loading doses and rarely need tests
  • Daily dose appears to be best, but monthly seems OK
  • Vitamin D is typically given to infants in the form of drops
       big difference in taste between brands
       can also use water-soluable form of vitamin D in milk, food, juice,
  • Infants have evolved to get a big boost of vitamin D immediately after birth
    Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    More than 100 IU/kg is probably better

Getting Vitamin D into infants
Many infants reject vitamin D drops, even when put on nipple
I speculate that the rejection is due to one or more of: additives, taste, and oils.
Infants have a hard time digesting oils, 1999  1997   and palm oils W.A. Price 1 2 3
Coconut oil, such as in D-Drops, is digested by infants. 1,   2   3
Bio-Tech Pharmacal Vitamin D has NO additves, taste, oil
One capsule of 50,000 Bio-Tech Pharmacal Vitamin D could be stirred into monthly formula
   this would result in ~1,600 IUs per day for infant, and higher dose with weight/age/formula consumption

Attached files

ID Name Comment Uploaded Size Downloads
6644 Hazell_et_al-2016-Pediatric_Obesity (1).pdf PDF 2016 admin 06 May, 2016 01:22 182.18 Kb 250
6385 Age 3.jpg admin 04 Feb, 2016 18:11 21.21 Kb 579
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