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High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022


High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling.

Preprint doi: https://doi.org/10.1101/2022.05.19.492715
Caela Long, Zahra Tara, Alex Casella, Julian Mark, View ORCID ProfileJeffrey Roizen

Increase in Vitamin D levels after 4 weeks
2000 IU/kilogram 20-30 ng/ml
10,000 IU per kilogram>30 ng/ml
With high-dose D: Grip increased, % fat decreased

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Mice with higher D used 10% more energy

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Table 1 : High dose dietary vitamin D preferentially allocates excess calories to muscle and growth instead of fat by increasing production and sensitivity and decreasing myostatin production, Normal-D increases leptin production, decreases myostatin proc leading to increased allocation of excess calories to muse increased strength. High-D increases leptin sensitivity and decreases myostatin production, leading to increased allocation of excess calories to muscle with increased strenath. as well as increased energy expenditure and linear growth.

Abstract
Obesity is the leading proportional cause for diabetes, heart disease and cancer. Obesity occurs because the body stores surplus calories as fat. Fat cells secrete a hormone, leptin, that modulates energy balance at the brain. Changes in fat mass are mirrored by changes in serum leptin. Increases in leptin cause the brain to decrease appetite and increase energy expenditure. However in obesity, leptin sensitivity is decreased which mutes leptin mediated changes in appetite and energy expenditure. We have limited understanding of what controls leptin production by fat or how sensitive the brain is to leptin. Muscle produces a hormone, myostatin, that plays an analogous role to the role that leptin plays in fat. Absent myostatin leads to increased muscle mass and strength. We also do not know what controls myostatin production or sensitivity. Although fat mass and muscle mass are closely linked, the interplay between leptin and myostatin remains unexplored. Vitamin D improves lean mass via what are thought to be primarily trophic effects at the muscle. Here we show that high dose dietary vitamin D preferentially allocates excess calories to muscle and growth instead of storage as fat by decreasing myostatin production and increasing leptin production and sensitivity. That is, high dose vitamin D improves organismal energy sensing. Obesity, aging and other chronic inflammatory diseases are associated with decreased muscle function and mass. Our work provides a physiologic framework for how high-dose vitamin D would be effective in these pathologies to increase allocation of calories to muscle instead of fat and reveals novel interplay between the myostatin and leptin signaling whereby myostatin conveys energy needs to modulate leptin effects on calorie allocation. Furthermore, our work reveals how physiologic seasonal variation in vitamin D may be important in controlling season-specific metabolism and calorie allocation to fat in winter and muscle in summer.
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VitaminDWiki - Overview Obesity and Vitamin D contains


VitaminDWiki - Overview Muscles and Vitamin D


VitaminDWiki pages with MUSCLE in title (110 as of May 2022)

This list is automatically updated

Items found: 113
Title Modified
More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 26 Nov, 2022
Exercise-induced muscle damage fought when enough vitamin D used for long enough – review Sept 2022 24 Sep, 2022
Frailty and low muscle mass both associated with low vitamin D – Aug 2013 14 Sep, 2022
Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 30 Jun, 2022
Omega-3 improves elderly muscles – 2 meta-analyses 06 Jun, 2022
Overview Muscles and Vitamin D 20 May, 2022
High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022 20 May, 2022
3X less muscle atrophy after ACL surgery if more than 40 ng of vitamin D – May 2022 14 May, 2022
Muscle Strength improved 1.4 to 19 percent by vitamin D3 (not D2) – systematic review June 2016 13 Feb, 2022
Role of Vitamin K in Bones and Muscles - Feb 2022 13 Feb, 2022
Some vitamin D is stored in skeletal muscles – multiple studies 27 Dec, 2021
Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 16 Oct, 2021
Sarcopenia (muscle loss) and Vitamin D 16 Oct, 2021
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Less muscle inflammation after exercise if high level of Vitamin D (50 ng) -July 2021 08 Jul, 2021
Low muscle strength predicts low vitamin D level in elderly – March 2021 06 May, 2021
Adding just a little vitamin D does not help (muscle mass in this case) – meta-analysis Jan 2021 06 Feb, 2021
Low muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – Dec 2020 04 Jan, 2021
4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT Jan 2020 21 Sep, 2020
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020 30 Jan, 2020
2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014 23 Dec, 2019
Muscles not improved by just Vitamin D weekly (also need exercise) – Dec 2019 17 Dec, 2019
Low vitamin D resulted in reduced genes to make muscles (in rats) – Nov 2019 11 Nov, 2019
Active muscles store vitamin D in the winter - Oct 2019 11 Oct, 2019
Omega-3 helps muscles – Aug 2019 24 Aug, 2019
Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019 10 Aug, 2019
8 Signs of Low Vitamin D - sweating, bones ache, muscle pain, poor immune, fatigue, slow healing etc. – YouTube Dec 2018 05 Aug, 2019
Vitamin D stored in muscle via Vitamin D Binding Protein – July 2019 30 Jul, 2019
Mechanisms of vitamin D action in skeletal muscle – June 2019 22 Jun, 2019
Vitamin D supplementation increases strength of lower muscles – Meta-analysis April 2019 01 May, 2019
Vitamin D does not help gain muscle mass (when only use small doses) – March 2019 03 Mar, 2019
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 23 Feb, 2019
Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019 12 Feb, 2019
Protein aids muscle gain – meta-analysis March 2018 02 Jan, 2019
Vitamin D and muscle – April 2019 07 Dec, 2018
Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018 14 Sep, 2018
Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 21 Aug, 2018
Dietary Protein, Muscle and Physical Function in the Very Old – July 2018 17 Aug, 2018
Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018 06 Aug, 2018
Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018 14 Jul, 2018
Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 13 Jul, 2018
Muscle problems are both treated and avoided by Vitamin D – April 2018 03 Jul, 2018
Seniors getting Vitamin D (but no exercise) for 3 months failed to increase muscle strength – RCT June 2018 03 Jul, 2018
Muscle, etc. problems if consume little vitamin D (mice) – June 2018 27 Jun, 2018
Muscle pain (Low Magnesium) plus Low Vitamin D associated with 10X more Cancer, etc (San Francisco) – Aug 2017 13 Apr, 2018
Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018 08 Apr, 2018
Fewer Breast Cancer deaths if more muscle (probably due to less fat, more Vitamin D) – April 2018 07 Apr, 2018
Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015 03 Mar, 2018
Headaches (chronic tension) 3X more likely to have low vitamin D – also muscle weakness and bone tenderness – May 2017 25 Jan, 2018
Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017 29 Aug, 2017
Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015 27 Jul, 2017
Muscle strength not increased by Vitamin D - 96 percent were not deficient – RCT April 2017 20 Jul, 2017
Infant muscle development best with 400 IU of vitamin D (not 800) – Sept 2015 13 Jul, 2017
Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016 08 Jun, 2017
Muscle strength not increased by Vitamin D when 96 percent already had enough – RCT April 2017 30 Apr, 2017
Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 08 Mar, 2017
More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017 02 Mar, 2017
Severely burned children recovered muscle capability much faster with daily 1000 IU of vitamin D – RCT March 2017 01 Mar, 2017
Hypothesis: Less severe muscle damage if vitamin D level had been normalized – July 2013 21 Feb, 2017
Large single-dose of Omega-3 reduced expected muscle damage – Feb 2017 21 Feb, 2017
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Sarcopenic added 1 lb of muscle in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Osteosarcopenic obesity (obese with low bone and muscle mass) twice as likely if low vitamin D – Oct 2016 31 Jan, 2017
More muscle torque associated with higher vitamin D – Jan 2017 05 Jan, 2017
Vitamin D increased muscle strength by 1% to 19% (varied with dose and duration) – review June 2016 22 Nov, 2016
Vitamin D increased muscle strength by 1 to 19 percent – review June 2016 22 Nov, 2016
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 22 Nov, 2016
Myotonic dystrophy a (rare genetic muscle problem) associated with low vitamin D – Nov 2016 18 Nov, 2016
Myotonic dystrophy (a rare genetic muscle problem) associated with low vitamin D – Nov 2016 18 Nov, 2016
Muscle strength is associated with vitamin D receptor gene variants – March 2016 12 Nov, 2016
Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015 31 Oct, 2016
Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 31 Oct, 2016
Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016 06 May, 2016
Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011 05 May, 2016
Sunshine is a cure for “weak and soft muscles” – 425 BC 22 Apr, 2016
Senior muscles increased somewhat with Omega-3 – RCT July 2015 18 Jan, 2016
Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015 05 Nov, 2015
More muscle response when have adequate vitamin D 27 Jul, 2015
Pelvic floor muscle strength is low after giving birth if vitamin D deficient – March 2015 20 Mar, 2015
Weight loss includes muscle loss unless add vitamin D, whey and leucine – RCT Feb 2015 07 Feb, 2015
Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014 27 Jan, 2015
Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013 27 Jan, 2015
Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013 27 Jan, 2015
Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013 27 Jan, 2015
People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014 20 Dec, 2014
Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014 18 Jul, 2014
Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013 05 May, 2014
MRI of elderly skeletal muscle lacking vitamin D – April 2014 30 Apr, 2014
Muscle cells differentiate into fat cells if there is low vitamin D in petrie dish – April 2013 30 Apr, 2014
Skeletal muscles helped by vitamin D – Review Feb 2014 08 Feb, 2014
Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 23 Dec, 2013
Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 19 Dec, 2013
Muscle strength not increased by raising vitamin D to only 30 ng – RCT Aug 2012 19 Dec, 2013
Vitamin D provides faster recovery after muscle overuse – April 2013 18 Dec, 2013
Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012 23 Oct, 2013
Evidence that vitamin D is also stored in muscle cells – Sept 2013 26 Sep, 2013
Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 10 Aug, 2013
Hypothesis: Low vitamin D is one of the causes of muscle weakness in alcoholics – Dec 2012 31 Jul, 2013
More muscle injuries in NFL players who were low on vitamin D – July 2011 13 Jul, 2013
Muscle inflammation 17X more probable if vitamin D deficient – Feb 2013 13 Jul, 2013
Muscle improved by increasing vitamin D if previously less than 24 ng – June 2013 02 Jul, 2013
Most immigrant women in Sweden had little vitamin D and lots of muscle pain – May 2013 22 May, 2013
Deadly amount of vitamin D speeds up recovery of crushed muscles in rats – Dec 2012 19 Apr, 2013
Relevance of Vitamin D in Bone and Muscle Health of Cancer Patients - Jan 2013 06 Dec, 2012
Vitamin D2 intervention increased elderly muscle strength – Nov 2010 10 Nov, 2012
Higher vitamin D helps regain muscle strength after knee surgery – July 2011 01 Sep, 2011
Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010 14 Sep, 2010
Skeletal Muscle weakness from lack of vitamin D fixed by adding Calcium and phosphorus – Aug 2010 11 Aug, 2010
Vitamin D, Muscle Function, and Exercise Performance in kids – June 2010 09 Jun, 2010
Vitamin D improving muscles may be due to improving phosphate levels – June 2010 03 Jun, 2010
Vit D associated with less muscle fat 11 Apr, 2010
Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019 No value for 'modification_date_major'

Created by admin. Last Modification: Friday May 20, 2022 17:53:37 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
17634 Increased Energy expenditure.jpg admin 20 May, 2022 15:25 20.71 Kb 130
17633 Grip Fat.jpg admin 20 May, 2022 15:16 28.35 Kb 145
17632 High Dose D, less obesity_CompressPdf.pdf PDF 2022 admin 20 May, 2022 15:01 301.90 Kb 61
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