Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns
Burns, Available online 16 September 2014
Anne-Françoise Rousseaua afrousseau at chu.ulg.ac.be, Marguerite Foidart-Desalleb, Didier Ledouxa, Christophe Remya, c, Jean-Louis Croisierc, Pierre Damasa, Etienne Cavalierd
Used barely enough vitamin D to make a difference
Failed to have many cofactors needed to rebuild bone: Magnesium, Vitamin K2, Silicon, Boron
See also VitaminDWiki
- Hypothesis: Extensive burns reduce vitamin D, which increase bone loss – Nov 2012
- Bone - Health category listing with many associated searches
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- Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K
- Magnesium may be more important to kids’ bone health than calcium – May 2013
- Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014
- Burn patients have little vitamin D and benefit when it is restored
Many of the same authors as the study on this page
Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury.
Monocentric randomized controlled trial.
Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000 IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol.
Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40 y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37–61) ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity.
This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life.People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014
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