The effects of vitamin D on skeletal muscle strength, muscle mass and muscle power: a systematic review and meta-analysis of randomized controlled trials.
J Clin Endocrinol Metab. 2014 Jul 17:jc20141742. [Epub ahead of print]
Beaudart C1, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, Petermans J, Reginster JY, Bruyère O.
1Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium;
Context There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle.
Objective To summarize with a meta-analyse the effects of vitamin D supplementation on muscle function.
Data sources A systematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts.
Study selection All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria. Data extraction Data were extracted by two independent reviewers.
Data synthesis Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (p=0.02). No significant effect was found on muscle mass (SMD 0.058; p=0.52) or muscle power (SMD 0.057; p=0.657).
Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level <30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 versus SMD 0.03; 95% CI -0.08 to 0.14).
Conclusions Vitamin D supplementation has a small positive impact on muscle strength but additional studies are needed to define optimal treatment modalities, including dose, mode of administration and duration.
Pages listed in BOTH the categories Sports and Seniors
- Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019
- Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019
- Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018
- Dietary Protein, Muscle and Physical Function in the Very Old – July 2018
- Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018
- Hypothesis: Sarcopenia needs Protein, Leucine, Omega-3, Vitamin D, and exercise – Aug 2018
- Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018
- Muscle problems are both treated and avoided by Vitamin D – April 2018
- Sarcopenia does not officially exist in Australia, but 1 in 3 of their seniors have it - July 2018
- Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT Feb 2018
- Overweight senior women with low vitamin D were 12X more likely to be weak – Feb 2018
- Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017
- Resistance exercise combined with Vitamin D is great for seniors – meta-analysis July 2017
- Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016
- Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017
- More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017
- Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016
- Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015
- Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014
- Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013
- Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013
- Physical performance of seniors increases with vitamin D up to 30 ng – Jan 2013
- Activity and being outdoors helps seniors – GPS and Vitamin D Dec 2012
- Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012
- Sarcopenia (muscle loss) and Vitamin D
- Senior women more physically able if vitamin D higher than 30 ng – Sept 2011
- Seniors with more than 20 ng of vitamin D were 14 percent stronger – May 2011
- Vitamin D2 intervention increased elderly muscle strength – Nov 2010
- Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010