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Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017

Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study.

Clin Nutr. 2017 Jan 17. pii: S0261-5614(17)30010-9. doi: 10.1016/j.clnu.2017.01.005. Epub ahead of print
Verlaan S1, Maier AB2, Bauer JM3, Bautmans I4, Brandt K5, Donini LM6, Maggio M7, McMurdo ME8, Mets T4, Seal C5, Wijers SL9, Sieber C10, Boirie Y11, Cederholm T12.

VitaminDWiki Summary

RCT for 13 weeks. at 18 centers, no exercise
A mere 800 IU of vitamin D

Any of the following would doubtlessly have added even more muscle mass

  • More Vitamin D
  • More Protein
  • Longer than 13 weeks
  • Exercise
  • Loading dose - to restore Vitamin levels to beneficial amount in days, not months

Clipped from PDF
“. . . vitamin D acted synergistically with leucine and insulin to stimulate muscle protein synthesis, likely through sensitizing the anabolic pathways induced by insulin and leucine’
See also VitaminDWiki

VitaminDWiki pages containing SARCOPENIA in title (16 as of Oct 2021)

This list is automatically updated

Items found: 17
Title Modified
Sarcopenia with obesity is more likely if dark skin, diabetes, OR COPD (all associated with low vitamin D) 16 Oct, 2021
Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 16 Oct, 2021
Sarcopenia (muscle loss) and Vitamin D 16 Oct, 2021
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Sarcopenia reduction: Protein, Leucine, Omega-3, Vitamin D, and exercise - hypothesis Aug 2018 30 Jan, 2020
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 23 Feb, 2019
Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 13 Jul, 2018
Sarcopenia does not officially exist in Australia, but 1 in 3 of their seniors have it - July 2018 03 Jul, 2018
Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017 10 Mar, 2017
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Hypothesis: Sarcopenia and other senior problems are related to low gastic acid 12 May, 2015
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hypothesis: Sarcopenia and other senior problems are related to low gastric acid 01 Feb, 2015
Vitamin D is one of the treatments for sarcopenia – Nov 2012 31 Jan, 2015
No correlation found between vitamin D and sarcopenia – German dissertation Jan 2013 22 Jan, 2013
Novel treatment approaches to cachexia and sarcopenia: 13 Apr, 2010


 Download the PDF from VitaminDWiki

Red-shaded area shows the RCT arm with both Vitamin D and Protein

Image

BACKGROUND:
Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.

OBJECTIVE:
To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.

METHODS AND DESIGN:
Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.

RESULTS:
At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h2), and relative appendicular muscle mass (aMM/body weight × 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.

CONCLUSIONS:
Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.

PMID: 28132725 DOI: 10.1016/j.clnu.2017.01.005

Attached files

ID Name Comment Uploaded Size Downloads
7733 Muscle mass.jpg admin 31 Jan, 2017 16:28 25.55 Kb 1161
7732 sarcopenic 2.pdf PDF 2017 admin 31 Jan, 2017 16:27 331.01 Kb 722
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