Am J Clin Nutr. 2015 Jul;102(1):115-22. doi: 10.3945/ajcn.114.105833. Epub 2015 May 20.
Smith GI1, Julliand S1, Reeds DN1, Sinacore DR2, Klein S1, Mittendorfer B3.
1 Center for Human Nutrition and.
2 Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO.
3 Center for Human Nutrition and mittendb at wustl.edu.
Men and women who were 60-85 ears old
Omega-3 daily for 6 months – amount was not stated in abstract
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Fact: Increasing Omega-3 increases vitamin D getting to cells
Fact: Increasing Vitamin D increases muscle strength
Wonder if this trial was just noticing: Omega-3 ==> more Vitamin D ==> more muscle
See also VitaminDWiki
- Vitamin D and Omega-3 category
- Overview: Omega-3 many benefits include helping vitamin D
- Omega-3 weekly is more bio-available than daily (rat study) – July 2015
- wonder if weekly Omega-3 is better for humans as well
- Supplements survey: Fish oil 1st, Vitamin D 4th, Magnesium 6th, Calcium 7th - March 2015
- Handgrip strength increased 9 percent in college athletes with 8 weeks of Omega-3 – RCT Feb 2022
- Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020
- Omega-3 helps muscles – Aug 2019
- Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019
- No NCAA player had a healthy Omega-3 index – Jan 2019
- Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018
- 2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014
- Olympic Committee consensus on Vitamin D, Omega-3, Zinc, etc– May 2018
- During NFL season – Omega-3 down by 2.5 points while Vitamin D up by 9 ng – March 2018
- Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015
- Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017
- Large single-dose of Omega-3 reduced expected muscle damage – Feb 2017
- Capillary blood flow increased with Omega-3 by increasing deformability of blood cells – July 2015
- Football Brain injuries prevented by Omega-3 – RCT Jan 2016
- Senior muscles increased somewhat with Omega-3 – RCT July 2015
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013
Age-associated declines in muscle mass and function are major risk factors for an impaired ability to carry out activities of daily living, falls, prolonged recovery time after hospitalization, and mortality in older adults. New strategies that can slow the age-related loss of muscle mass and function are needed to help older adults maintain adequate performance status to reduce these risks and maintain independence.
We evaluated the efficacy of fish oil-derived n-3 (ω-3) PUFA therapy to slow the age-associated loss of muscle mass and function.
Sixty healthy 60-85-y-old men and women were randomly assigned to receive n-3 PUFA (n = 40) or corn oil (n = 20) therapy for 6 mo. Thigh muscle volume, handgrip strength, one-repetition maximum (1-RM) lower- and upper-body strength, and average power during isokinetic leg exercises were evaluated before and after treatment.
Forty-four subjects completed the study [29 subjects (73%) in the n-3 PUFA group; 15 subjects (75%) in the control group].
Compared with the control group, 6 mo of n-3 PUFA therapy increased
- thigh muscle volume (3.6%; 95% CI: 0.2%, 7.0%),
- handgrip strength (2.3 kg; 95% CI: 0.8, 3.7 kg), and
- 1-RM muscle strength (4.0%; 95% CI: 0.8%, 7.3%) (all P < 0.05)
and tended to increase average isokinetic power (5.6%; 95% CI: -0.6%, 11.7%; P = 0.075).
Fish oil-derived n-3 PUFA therapy slows the normal decline in muscle mass and function in older adults and should be considered a therapeutic approach for preventing sarcopenia and maintaining physical independence in older adults. This study was registered at clinicaltrials.gov as NCT01308957.
© 2015 American Society for Nutrition.