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Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021

Serum vitamin D status inversely associates with a prevalence of severe sarcopenia among female patients with rheumatoid arthritis

Sci Rep. 2021 Oct 14;11(1):20485. doi: 10.1038/s41598-021-99894-6.
Hiroto Minamino # 1 2, Masao Katsushima # 3, Mie Torii 4, Wataru Yamamoto 5, Yoshihito Fujita 1, Kaori Ikeda 1, Emi Okamura 1, Kosaku Murakami 3, Ryu Watanabe 6 7, Koichi Murata 6 8, Hiromu Ito 6 8 9, Masao Tanaka 6, Hidenori Arai 10, Shuichi Matsuda 8, Akio Morinobu 3 6, Nobuya Inagaki 1, Motomu Hashimoto 6 7


Sarcopenia (muscle loss) and Vitamin D page contains

To gain muscle, many studies have found that you need some of the following:
Exercise - just even walking (Intermittent high intensity exercise is much better)
Vitamin D - at least 800 IU/day,
    Loading dose will show improvements in weeks instead of 4+ months
Protein - perhaps 1gm/kg/day in a form appropriate for existing stomach acid
Calcium - 300 mg?

See also Bone Health   reduce falls and fractures   Fraility and Vitamin D - many studies   Overview Muscles and Vitamin D

VitaminDWiki pages containing SARCOPENIA in title
(16 as of Oct 2021)

This list is automatically updated

Items found: 17
Title Modified
Sarcopenia with obesity is more likely if dark skin, diabetes, OR COPD (all associated with low vitamin D) 16 Oct, 2021
Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 16 Oct, 2021
Sarcopenia (muscle loss) and Vitamin D 16 Oct, 2021
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Sarcopenia reduction: Protein, Leucine, Omega-3, Vitamin D, and exercise - hypothesis Aug 2018 30 Jan, 2020
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 23 Feb, 2019
Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 13 Jul, 2018
Sarcopenia does not officially exist in Australia, but 1 in 3 of their seniors have it - July 2018 03 Jul, 2018
Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017 10 Mar, 2017
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Hypothesis: Sarcopenia and other senior problems are related to low gastic acid 12 May, 2015
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hypothesis: Sarcopenia and other senior problems are related to low gastric acid 01 Feb, 2015
Vitamin D is one of the treatments for sarcopenia – Nov 2012 31 Jan, 2015
No correlation found between vitamin D and sarcopenia – German dissertation Jan 2013 22 Jan, 2013
Novel treatment approaches to cachexia and sarcopenia: 13 Apr, 2010

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Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum 25-hydroxyvitamin D [25(OH)D] affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 female patients with RA (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait speed. Furthermore, multivariable logistic regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99-18.08).The same association was observed when the cut-off value was set at 20 ng/ml. In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH)D status. In conclusion, vitamin D status was inversely associated with severe sarcopenia, low physical performance, and low skeletal muscle mass. Modification of vitamin D status including vitamin D supplementation should be investigated as a therapeutic strategy for sarcopenic patients with RA.


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