Mar Drugs. 2015 Nov 19;13(11):6977-7004. doi: 10.3390/md13116977.
Jeromson S1, Gallagher IJ2, Galloway SD3, Hamilton DL4.
- Omega-3 might manage T2 Diabetes – March 2018
- Diabetes 5.6 X more likely if low vitamin D 4 years before – March 2018
Items in both categories Omega-3 and Sports are listed here:
- Omega-3 helps muscles – Aug 2019
- Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019
- No NCAA player had a healthy Omega-3 index – Jan 2019
- Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018
- 2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014
- Olympic Committee consensus on Vitamin D, Omega-3, Zinc, etc– May 2018
- During NFL season – Omega-3 down by 2.5 points while Vitamin D up by 9 ng – March 2018
- Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015
- Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017
- Large single-dose of Omega-3 reduced expected muscle damage – Feb 2017
- Capillary blood flow increased with Omega-3 by increasing deformability of blood cells – July 2015
- Football Brain injuries prevented by Omega-3 – RCT Jan 2016
- Senior muscles increased somewhat with Omega-3 – RCT July 2015
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013
Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be modified by the prior nutritional status of the muscle. The influence of nutrition on skeletal muscle has the potential to substantially impact physical function and whole body metabolism.
Animal and cell based models show that omega-3 fatty acids, in particular those of marine origin, can influence skeletal muscle metabolism. Furthermore, recent human studies demonstrate that omega-3 fatty acids of marine origin can influence the exercise and nutritional response of skeletal muscle. These studies show that the prior omega-3 status influences not only the metabolic response of muscle to nutrition, but also the functional response to a period of exercise training. Omega-3 fatty acids of marine origin therefore have the potential to alter the trajectory of a number of human diseases including the physical decline associated with aging. We explore the potential molecular mechanisms by which omega-3 fatty acids may act in skeletal muscle, considering the n-3/n-6 ratio, inflammation and lipidomic remodelling as possible mechanisms of action. Finally, we suggest some avenues for further research to clarify how omega-3 fatty acids may be exerting their biological action in skeletal muscle.
PMID: 26610527 PMCID: PMC4663562 DOI: 10.3390/md13116977