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Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018

Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability.

J Am Med Dir Assoc. 2018 Aug 1. pii: S1525-8610(18)30326-8. doi: 10.1016/j.jamda.2018.06.006.

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Items in both categories Seniors and Sports are listed here:


Borim FSA1, Alexandre TDS2, Neri AL3, Máximo RO4, Silva MF3, de Oliveira C5.
1 Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil. flarbex at hotmail.com.
2 Department of Epidemiology and Public Health, University College London, London, United Kingdom; Dept of Gerontology, Federal University of Sao Carlos, Sao Carlos, Brazil.
3 Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
4 Department of Physical Therapy, Federal University of Sao Carlos, Sao Carlos, Brazil.
5 Department of Epidemiology and Public Health, University College London, London, United Kingdom.

BACKGROUND AND OBJECTIVE:
There is little epidemiologic evidence considering the combined effect of dynapenia and low 25-hydroxyvitamin D [25 (OH) D] on incident disability. Our aim was to investigate whether the combination of dynapenia and low 25 (OH) D serum levels increases the risk of activities of daily living (ADL) incident disability.

DESIGN: Prospective cohort study.

SETTINGS: English Longitudinal Study of Aging.

PARTICIPANTS: A total of 4630 community-dwelling adults aged 50 years and older without ADL disability at baseline.

MEASUREMENTS:
The baseline sample was categorized into 4 groups (ie, nondynapenic/normal 25 (OH) D, low 25 (OH) D only, dynapenic only, and dynapenic/low 25 (OH) D according to their handgrip strength (<26 kg for men and <16 kg for women) and 25 (OH) D (≤50 nmol/L). The outcome was the presence of any ADL disability 2 years after baseline according to the modified Katz Index. Incidence rate ratios (IRRs) adjusted by sociodemographic, behavioral, and clinical characteristics were estimated using Poisson regression.

RESULTS:
The fully adjusted model showed that older adults with dynapenia only and those with lower serum levels of 25 (OH) D combined with dynapenia had higher incident ADL disability risk compared with nondynapenic and those with normal serum levels of 25 (OH) D. The IRRs for lower 25 (OH) D serum levels combined with dynapenia were higher than for dynapenia only, however, the confidence intervals (CIs) showed similar effect for these 2 groups. The IRRs were 1.31 for low 25(OH) D only (95% CI 0.99-1.74), 1.77 for dynapenia only (95% CI 1.08-2.88), and 1.94 for combined dynapenia and low 25(OH)D (95% CI 1.28-2.94).

CONCLUSIONS:
Dynapenia only and dynapenia combined with low 25 (OH) D serum levels were important risk factors for ADL disability in middle-aged individuals and older adults in 2 years of follow-up.

PMID: 30077597 DOI: 10.1016/j.jamda.2018.06.006

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