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Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022


Association Between Vitamin D Supplementation and Statin-Associated Muscle Symptoms: A Systematic Review

High Blood Press Cardiovasc Prev . 2022 Jun 29. doi: 10.1007/s40292-022-00526-5 PDF behind paywall
Chong Boon Teo # 1, Pek Yan Tan # 1, Ryan Yong Kiat Tay # 1, Joan Khoo 2, Gerald F Watts 3 4, Wann Jia Loh 5

\Introduction: Although low vitamin D levels are associated with statin-associated muscle symptoms (SAMS), it remains unclear if vitamin D supplementation leads to symptom improvement.

Aim: We performed a systematic review to evaluate the association of vitamin D supplementation with resolution of SAMS.

Methods: We searched Medline (PubMed), Embase and Cochrane Library till 12 December 2021. Full length articles that reported on the association between vitamin D supplementation in adult patients with SAMS were included.

Results: We identified 8 interventional studies comprising 669 participants. Majority of the participants were of Caucasian ethnicity and the mean age of participants ranged from 59.5 to 64.8 years old. The studies recruited patients with initial mean pre-treatment vitamin D levels ranging from 17.8 to 22.0ng/mL. Follow up duration ranged from 2 to 24 months and mean post-treatment vitamin D levels ranged from 34.3 to 56.0ng/mL. We found that vitamin D supplementation was associated with improved statin tolerance in 509 out of 606 (83.9%) patients across the 7 studies which reported patient numbers after supplementation (95% CI = 0.81-0.87, I2 = 72% n = 7). None of the studies were randomized controlled trials (RCTs) and hence placebo effect of vitamin D could not be ruled out. Nocebo effect of statin was also not assessed by any of the studies.

Conclusion: Vitamin D supplementation in patients with mild-moderate vitamin D insufficiency was associated with improvement of SAMS. However, quantitative efficacy analysis was not possible and this observed association is likely confounded by nocebo and placebo effects. RCTs are required to conclusively assess the utility of vitamin D supplementation in improving SAMS.


VitaminDWiki pages with STATIN in title (25 as of June 2022)

This list is automatically updated

Items found: 25
Title Modified
Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 30 Jun, 2022
Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis July 2021 23 Jul, 2021
Statin side-effects are reduced by Vitamin D – US patent Application – April 2019 14 Nov, 2019
Statin pain eliminated by 7100 IU vitamin D (50000 IU weekly) – July 2011 21 Jul, 2019
Most Profitable Pill in Medical History Is Based on Flawed Science (Statins) May 2019 02 Jun, 2019
Statins and vitamin D 14 Jul, 2018
Low-dose statin plaque formation stopped by Omega-3 – RCT Dec 2017 24 Jan, 2018
Statin-induced Myalgias corrected with 100000 weekly Vitamin D2 20 Jul, 2017
Statin use increased probability of diabetes in women by 48 percent – perhaps via vitamin D Jan 2012 19 Mar, 2017
Statin use increased probability of diabetes by 48 percent – perhaps via vitamin D Jan 2012 19 Mar, 2017
The statin Crestor dramatically increases levels of vitamin D in the blood – Jan 2012 17 May, 2016
Some statins increase skin cancer risk by 40 percent (reducing vitamin D levels) – Jan 2016 10 Jan, 2016
Theories on the interaction between statins and vitamin D – 2012 10 Jan, 2016
If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015 22 May, 2015
One statin decreased vitamin D levels but the other did not – March 2010 14 Apr, 2015
Not all statins increase vitamin D levels – Dec 2010 14 Apr, 2015
Off topic – Hypertension and statin pain reduced by Coenzyme Q10 – 2010 26 Jan, 2015
Statins with low vitamin D increased chance of musculoskeletal pain by 2X – Jan 2015 29 Nov, 2014
Statin pain associated with 10 ng less vitamin D – meta-analysis Oct 2014 24 Oct, 2014
Diabetics have problems with low Magnesium , especially if taking statins – Aug 2013 08 May, 2014
Statin-induced Myalgias corrected with 100000 weekly Vitamin D 04 May, 2014
Off topic: Statins associated with increased cataracts (wonder about low vitamin D) - Sept 2013 29 Sep, 2013
Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013 28 Aug, 2013
Breast cancer 2X more likely if have taken statins for 10 years – July 2013 11 Jul, 2013
Statins associated with 14X increase in Polymyalgia Rheumatica (a new disease) – Aug 2012 09 Nov, 2012

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