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Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012

Sarcopenia: Pharmacology today and tomorrow

Journal of Pharocology and Experimental Theraputics August 28, 2012
Marco P Brotto brottom at umkc.edu, and Eduardo L Abreu
University of Missouri-Kansas City

Sarcopenia remains largely undiagnosed and undertreated, because of the lack of a universally accepted definition, effective ways to measure it, and identification of the outcomes that should guide treatment efficacy. An ever growing number of clinicians and researchers along with funding and regulatory agencies have gradually recognized that sarcopenia is a human condition that requires both prevention and treatment. In this "Pharmacology in Perspective: article, we briefly reviewed sarcopenia; its common and less known pharmacological treatments, and attempted to define sarcopenia in its broader context, and presented some new ideas for potential future treatment for this devastating condition. ?

Figure 1:Interventions

Image


The following is clipped from the PDF which is at the bottom of this page

d) Vitamin D:

It is now very well established that low levels of blood vitamin D levels are associated with decreased muscle strength and statin-induced myopathy, but vitamin D supplementation results are still under investigation. Given the beneficial results of calcium + vitamin D supplementation on bone function (Recker et al., 2006), it is expected that correcting vitamin D levels will also be beneficial for muscle function. Furthermore, results might also be dependent on the form of Vitamin D used and whether vitamin D intake is combined or not with calcium. We believe that it will be important to follow individuals longitudinally and test their muscle function as a function of age and levels of calcium plus vitamin D. In addition, vitamin D supplementation might be beneficial for overall health, since Lappe and colleagues have recently reported a 63% reduction in all types of cancers in subjects receiving vitamin D3 (figure 2C) supplementation (Lappe et al., 2007).


Loss of muscle strength seems to happens when away from sunlight:

  • Age – especially if in a senior center, no longer in parks, no longer gardening, etc.
  • Long time in bed (hospital, etc)
  • Long time in space

See also VitaminDWiki

VitaminDWiki pages containing SARCOPENIA in title (16 as of Oct 2021)

This list is automatically updated

Items found: 17
Title Modified
Sarcopenia with obesity is more likely if dark skin, diabetes, OR COPD (all associated with low vitamin D) 16 Oct, 2021
Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 16 Oct, 2021
Sarcopenia (muscle loss) and Vitamin D 16 Oct, 2021
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Sarcopenia reduction: Protein, Leucine, Omega-3, Vitamin D, and exercise - hypothesis Aug 2018 30 Jan, 2020
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 23 Feb, 2019
Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 13 Jul, 2018
Sarcopenia does not officially exist in Australia, but 1 in 3 of their seniors have it - July 2018 03 Jul, 2018
Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017 10 Mar, 2017
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Hypothesis: Sarcopenia and other senior problems are related to low gastic acid 12 May, 2015
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hypothesis: Sarcopenia and other senior problems are related to low gastric acid 01 Feb, 2015
Vitamin D is one of the treatments for sarcopenia – Nov 2012 31 Jan, 2015
No correlation found between vitamin D and sarcopenia – German dissertation Jan 2013 22 Jan, 2013
Novel treatment approaches to cachexia and sarcopenia: 13 Apr, 2010

Attached files

ID Name Comment Uploaded Size Downloads
1580 Sarcopenia.jpg admin 29 Aug, 2012 13:52 40.08 Kb 17215
1579 Sarcopenia - Pharmacology of Today and Tomorrow.pdf PDF admin 29 Aug, 2012 13:39 416.60 Kb 1375
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