Low vitamin D might be one of the causes of obesity – several studies

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Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function – Nov 2023

Nutrients 2023, 15(22), 4832; https://doi.org/10.3390/nu15224832
by Shiqi Lu andZhen-Bo Cao School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China

Adipose tissue encompasses various types, including White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and beige adipose tissue, each having distinct roles in energy storage and thermogenesis. Vitamin D (VD), a fat-soluble vitamin, maintains a complex interplay with adipose tissue, exerting significant effects through its receptor (VDR) on the normal development and functioning of adipocytes. The VDR and associated metabolic enzymes are widely expressed in the adipocytes of both rodents and humans, and they partake in the regulation of fat metabolism and functionality through various pathways. These encompass adipocyte differentiation, adipogenesis, inflammatory responses, and adipokine synthesis and secretion. This review primarily appraises the role and mechanisms of VD in different adipocyte differentiation, lipid formation, and inflammatory responses, concentrating on the pivotal role of the VD/VDR pathway in adipogenesis. This insight furnishes new perspectives for the development of micronutrient-related intervention strategies in the prevention and treatment of obesity.
Clipped from PDF

• "While the precise relationship between the VDR in VAT and serum 1,25(OH)2D3 has yet to be fully elucidated, the current findings provide support for a dose–response relationship between the severity of VDD and low VDR expression"
• "In the absence of differences in food and energy intake, high-fat diet-fed VDD animals exhibited significantly higher epididymal fat deposition compared to high-fat diet-fed VD-sufficient animals,... "
• "In summary, there exists a strong association between VD levels and the onset and progression of obesity,..."
• "The accumulation of VAT stands as the most sensitive and crucial indicative factor for identifying the presence of VDD high-risk individuals. "

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Vitamin D Deficiency: Consequence or Cause of Obesity? - Sept 2019

Medicina (Kaunas). 2019 Sep; 55(9): 541. doi: 10.3390/medicina55090541
Luka Vranić, Ivana Mikolašević, and Sandra Milić*

Obesity is defined as an excess amount of body fat and represents a significant health problem worldwide. High prevalence of vitamin D (VD) deficiency in obese subjects is a well-documented finding, most probably due to volumetric dilution into the greater volumes of fat, serum, liver, and muscle, even though other mechanisms could not completely be excluded, as they may contribute concurrently. Low VD could not yet be excluded as a cause of obesity, due to its still incompletely explored effects through VD receptors found in adipose tissue (AT). VD deficiency in obese people does not seem to have consequences for bone tissue, but may affect other organs, even though studies have shown inconsistent results and VD supplementation has not yet been clearly shown to benefit the dysmetabolic state. Hence, more studies are needed to determine the actual role of VD deficiency in development of those disorders. Thus, targeting lifestyle through healthy diet and exercise should be the first treatment option that will affect both obesity-related dysmetabolic state and vitamin D deficiency, killing two birds with one stone. However, VD supplementation remains a treatment option in individuals with residual VD deficiency after weight loss.
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169 studies citied this study as of Nov 2023

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VitaminDWiki - High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022

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VitaminDWiki - Unhealthy obesity 5 percent more likely with each ng less Vitamin D – Nov 2020

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VitaminDWiki – Overview Obesity and Vitamin D contains:

• FACT: People who are obese have less vitamin D in their blood
• FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
• FACT: When obese people lose weight the vitamin D level in their blood increases
• FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
• FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
• FACT: Less weight gain by senior women with > 30 ng of vitamin D
• FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
• FACT: Obese lost 3X more weight by adding $10 of Vitamin D
• FACT: Those with darker skins were more likely to be obese Sept 2014
• OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
• OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
  • and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
• SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
• SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
    risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
• Obesity category has 428 items See also: Weight loss and Vitamin D - many studies   Child Obesity and Vitamin D - many studies

Obese need more Vitamin D

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

• Normal weight     Obese     (50 ng = 125 nanomole)