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Micronutrients for COVID-19: Vitamin D, Vitamin C, Melatonin, Zinc, Se, etc. - Dec 2020

Micronutrients for COVID-19 and Viral Infections
- international Society of Orthomolecular Medicinen

Additional articles: https://isom.ca/micronutrients-viral-infections/

Vitamin C

Vitamin C: An adjunctive therapy for respiratory infection, sepsis and COVID-19. Nutrients. 2020; 12(12) – https://doi.org/10.3390/nu12123760

The use of IV Vitamin C for patients with COVID-19: A case series. Expert Rev Anti Infect Thera. 2020; 18(12) – https://doi.org/10.1080/14787210.2020.1794819

The emerging role of Vitamin C in the prevention and treatment of COVID-19. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113286

Vitamin D

The benefits of Vitamin D supplementation for athletes: Better performance and reduced risk of COVID-19. Nutrients. 2020; 12(12) – https://doi.org/10.3390/nu12123741

Vitamin D3 as potential treatment adjuncts for COVID-19. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113512

Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: The GERIA-COVID Quasi-Experimental Study. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113377

Evidence regarding Vitamin D and risk of COVID-19 and its severity. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113361

The role of micronutrients in support of the immune response against viral infections. Nutrients. 2020;12(10) – https://doi.org/10.3390/nu12103198

Role of Vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020; 13(10) – https://doi.org/10.1016/j.jiph.2020.06.021

Melatonin (many references added by VitaminDWiki)

  • Melatonin usage was found to lower the chance of a positive COVID-19 test by 28% - Feb 2021 FREE PDF
  • Melatonin is significantly (7x) associated with survival of intubated COVID-19 patients - preprint Oct 18 , 2020 PDF
  • Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections - March 2021- PDF

Evaluation of the efficacy and safety of melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial. NTrials. 2020; 21(1) – https://doi.org/10.1186/s13063-020-04737-w

COVID-19 protocol proposed in India includes Vitamin D - Nov 12, 2020 includes Melatonin

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings. Virus Res. 2020; 287– https://doi.org/10.1016/j.virusres.2020.198108

Is melatonin deficiency a unifying pathomechanism of high risk patients with COVID-19? Life Sci. 2020; 256 – https://doi.org/10.1016/j.lfs.2020.117902
Some reasons to believe that Melatonin could work ( from M.M Jan 2021)
1. HMGB1 inhibition
2. NFkB suppression
3. Nrf2 up regulation
4.TNFa, IL-1b, IL-6 IL-8 reduction
5. IL-10 elevation
6. NLRP3 inhibition

N-acetylcysteine (NAC)

N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2. Med Hypotheses. 2020; 143 - https://doi.org/10.1016/j.mehy.2020.109862


Selenium deficiency is associated with mortality risk from COVID-19. Nutrients. 2020; 12(7) – https://doi.org/10.3390/nu12072098

Selenium supplementation in the prevention of coronavirus infections (COVID-19). Med Hypotheses. 2020; 143 – https://doi.org/10.1016/j.mehy.2020.109878


COVID-19: Poor outcomes in patients with zinc deficiency. Int J Infect Dis. 2020; 100 – https://doi.org/10.1016/j.ijid.2020.09.014

Micronutrients and Nutrition

Effective immune functions of micronutrients against SARS-CoV-2. Nutrients. 2020; 12(10) – https://doi.org/10.3390/nu12102992

Nutritional status of patients with COVID-19. Int J Infect Dis. 2020; 100 – https://doi.org/10.1016/j.ijid.2020.08.018

Mini-review on the roles of Vitamin C, Vitamin D, and selenium in the immune against COVID-19. Molecules. 2020; 25(22) – https://doi.org/10.3390/molecules25225346

VitaminDWiki believes that the others help, but,

COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries

Items in both categories Zinc and Virus:

Items in both categories Resveratrol and Virus:

Created by admin. Last Modification: Sunday January 2, 2022 21:38:13 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
15293 C19-Melatonin, Vit D DeNicolantonio, McCarty.pdf admin 21 Mar, 2021 727.58 Kb 280
15292 intubated preprint_compressed.pdf admin 21 Mar, 2021 714.75 Kb 364