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2.7 fewer COVID-19 hospital deaths in those having more than 30 ng of vitamin D – Mayo Jan 9, 2021

Vitamin D Status is Associated With In-hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients

Mayo Clinic Proceedings. online 9 January 2021, https://doi.org/10.1016/j.mayocp.2021.01.001
Angeliki M.AngelidiMD PhDa∗Matthew J.BelangerMDa∗Michael K.LorinskyMDaDimitriosKaramanisPhDbNataliaChamorro-ParejaMDcdJenniferOgnibeneBAcLeonidasPalaiodimosMD MSccdeChristos S.MantzorosMD DScaf

VitaminDWiki

Note: - several studies have found that >40 ng is much better than >30 ng

Suspect if this data were re-analyzed for >40 ng that 2.7X ==>10X


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As of Sept 20, 2021, the page had:  34 trials6 trial results,   23 meta-analyses and reviews,   63 observations,   35 recommendations,   55 associations,  89 speculations,  48 videos   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   26 risk factors are ALL associated with low Vit D,   Recent Virus pages   Fight COVID-19 with 50K Vit D weekly   Vaccines

 Download the PDF from VitaminDWiki

:Appears to be a 9% decrease in mortality per each additional ng of vitamin D
Image

Objective
To explore the possible associations of serum 25-hydroxyvitamin D concentration [25(OH)D] with COVID-19 in-hospital mortality and need for invasive mechanical ventilation.

Patients and Methods
A retrospective, observational, cohort study was conducted at two tertiary academic medical centers in Boston and New York. Eligible participants were hospitalized adult patients with laboratory-confirmed COVID-19 between 1 February 2020 and 15 May 2020. Demographic, clinical characteristics, comorbidities, medications, and disease-related outcomes were extracted from electronic medical records.

Results
The final analysis included 144 patients with confirmed COVID-19 (median age: 66 years, 44.4% male). Overall mortality was 18%, while patients with 25(OH)D levels ≥30 ng/mL had lower rates of mortality compared to those with 25(OH)D levels <30 ng/mL (9.2% vs. 25.3%, P=.02). In the adjusted multivariable analyses, 25(OH)D as a continuous variable was independently significantly associated with lower in-hospital mortality (OR, 0.94; 95% CI, 0.90-0.98; P=.007) and need for invasive mechanical ventilation (OR, 0.96; 95% CI, 0.93-0.99; P=.01). Similar data were obtained when 25(OH)D was studied as a continuous variable after logarithm transformation and as a dichotomous (<30ng/mL vs. ≥30ng/mL) or ordinal variable (quintiles), in the multivariable analyses.

Conclusion
Among patients admitted with laboratory-confirmed COVID-19, 25(OH)D levels were inversely associated with in-hospital mortality and the need for invasive mechanical ventilation. Further observational studies are needed to confirm these findings and randomized clinical trials to assess the role of vitamin D administration in improving the morbidity and mortality of COVID-19.


Comorbidities from PDF
74% hypertension,
55% hyperlipidemia,
43.8% diabetes mellitus type 2
14% history of coronary artery disease
13% history of cerebrovascular disease
18.1%. Asthma,
15.3%, COPD
12.5% obstructive sleep apnea

In hospital
63.9% had increased oxygen requirements,
27.1% required invasive mechanical ventilation,
39% transferred to the ICU.
47.2% acute kidney injury
11.1% required renal replacement therapy.


Created by admin. Last Modification: Sunday January 24, 2021 19:44:37 GMT-0000 by admin. (Version 10)

Attached files

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14911 9 percent per ng.jpg admin 24 Jan, 2021 18:06 33.43 Kb 232
14910 Mayo mortality.pdf PDF 2021 admin 24 Jan, 2021 18:05 668.96 Kb 76
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