Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review
Nutrients 2021, 13(4), 1339; https://doi.org/10.3390/nu13041339
by Moustapha Dramé 1,2,*OrcID,Cécilia Cofais 3,Maxime Hentzien 4,Emeline Proye 5,Pécory Souleymane Coulibaly 5,David Demoustier-Tampère 5,Marc-Henri Destailleur 5,Maxime Lotin 5,Eléonore Cantegrit 5,Agnès Cebille 5,Anne Desprez 5,Fanny Blondiau 5OrcID,Lukshe Kanagaratnam 6 andLidvine Godaert 5,*
Vitamin D Supplementation and Death (subset of table)
Vitamin D Deficiency and Death (subset of table)
Virus and Seniors
- Vitamin D might also help the Long-COVID older adult – Jan 2023
- Increased risk of many neuro problems after COVID (1.4 X youths, 1.2X seniors) – Aug 2022
- Each COVID reinfection causes more severe disease in miltary veterans (independant of vaccination) - July 2022
- Long-Haul more prevalent among seniors - June - 2022
- COVID in seniors 5X less likely to be severe if vegetarian (small study) – April 2022
- 2.9 X less risk of COVID ICU if seniors had supplemented with Vitamin D (any amount) – April 2022
- COVID Hospitalization vs age and variant - Dec 10, 2021
- Younger are much less likely to die of COVID than elderly (posters) - Nov 2021
- Only 35,000 died in US of COVID who previously had been healthy
- Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT Oct 2021
- Half of COVID-19 death rate differences explained by rates of elderly influenza vaccination and low vitamin D – April 2021
- Vaccine response improved by Vitamin D (Shingles in this case) – Jan 2021
- Elderly nutrition and COVID-19 – systematic review July 2021
- Magnesium in Infectious Diseases in Older People - Jan 2021
- Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021
- 600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- Nursing homes could reduce risk of COVID-19 with Vitamin D – June 30, 2020
- Meningitis and other brain infections should be prevented by Vitamin D – June 2014
- Influenza, seniors and vitamin D – Jan 2012
Mortality and Virus studies
- Excess Deaths in Australia jumped up in 2022– preprint Feb 2023
- Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
- Number needed to vaccinate to prevent 1 Omicron death: 30,000 for age 60-70 - Sept 2022
- COVID survival in Europe in 2020 best predicted by population-level Vitamin D (of 13 variables) – July 2022
- Elderly who had been in COVID ICU were 4X more likely to die if low vitamin D – Nov 2022
- More COVID mortality if less than 20 ng of Vitamin D (Mexico) – May 2022
- 15,000,000 excess deaths in 2 years - May 2022
- COVID death 5.2X more likely if Vitamin D deficient – May 2022
- 29 X more likely to die of COVID if less than 20 ng of Vitamin D - March 2022
- Giving Vitamin D reduced COVID Mortality– Review of 11 studies – March 2022
- 18 million excess global deaths in past 2 years: COVID plus collateral damage - Lancet March 2022
- COVID severity and death more likely if low vitamin D (Egypt this time) - March 2022
- US nursing homes are epicenters for COVID deaths (200,000) - Feb 2022
- Ivermectin taken before COVID decreased death rate by 68 percent (3,000 with Ivermectin vs 3,000 without) - Dec 24, 2021
- Increase in non-COVID deaths (ages 18-64) in Indiana, India, etc. - Jan 5, 2022
- Only 35,000 died in US of COVID who previously had been healthy
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- COVID-19 patients getting 300,000 IU of Vitamin D were 5X less likely to die – Sept 2021
- Predict 2X more likely to die of COVID-19 if vitamin D Deficient (Iran 2020) – Sept 2021
- COVID-19 mortality not associated with Vitamin D (everyone had very low levels) -Sept 2021
- COVID-19 mortality for Blacks is 5X that for whites in 2 LA Hospitals - July 2021
- COVID-19 mortality was associated with vitamin D deficiency of 47 countries – July 2021
- Similar death rate for Vaccination and COVID-19 study and video – June 24, 2021
- COVID-19 death in hospital 5X more likely if low vs high vitamin D – preprint June 2021
- COVID-19 deaths 1.7X more likely if low vitamin D (even after “adjusting” for low D health problems) – May 2021
- COVID-19 deaths 1.5X less likely if more than 40 ng of vitamin D – US VA – April 2021
- Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021
- Less COVID-19 infection, mortality in countries with higher Vitamin D (Asia in this case) – May 2021
- COVID-19 was the third-leading cause of death in the US, especially in those with dark skins - April 1, 2021
- Risk of COVID-19 death was 4.9 X higher if very low vitamin D – March 31, 2021
- COVID-19 mortality 2X higher if low Vitamin D (Mexican hospital, preprint) - March 2021
- All COVID-19 patients had low vitamin D, the lowest were more likely to die – Feb 18, 2021
- 2.7 fewer COVID-19 hospital deaths in those having more than 30 ng of vitamin D – Mayo Jan 9, 2021
- Worse COVID-19 patients got 400,000 IU of vitamin D, deaths cut in half – Jan 14, 2021
- Iranians with COVID-19 were 2.3 X more likely to die if low vitamin D – Jan 2021
- Poor COVID-19 prognosis was 6 X more likely if low vitamin D – Jan 21, 2021
- Less than 10 dollars of Vitamin D per COVID-19 life saved in Myanmar - Jan 2021
- 2.8 X fewer COVID-19 nursing home deaths if add 10,000 IU Vitamin D daily for a week (small observation)- Jan 2021
- Italian nursing home COVID-19 – 4X less likely to die if taking Vitamin D– Dec 22, 2020
- Shift workers 2X more likely to get COVID-19 (low Vitamin D) - Dec 2020
- Those getting high dose vitamin D were 7 X less likely to die of COVID-19 - Dec 11, 2020
- COVID-19 male mortality increased 3.9 X if low vitamin D – observation Nov 25, 2020
- Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- COVID-19 was killing dark-skinned doctors, then they got a Vitamin D recommendation
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- 14.7 X more likely to die of COVID-19 if less than 12 ng of Vitamin D (185 Germans) – Sept 10, 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
- COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D)
COVID-19 treated by Vitamin D - studies, reports, videos
- As of Aug 22, 2023, the VitaminDWiki COVID page had: 19 trial results, 37 meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries
Download the PDF from VitaminDWiki
Background: Vitamin D has diverse and extensive effects on the immune system, including activating innate immunity and reducing the overactive adaptive immune response. A systematic review was performed to identify and synthesize the best available evidence on the association between vitamin D level and risk of COVID-19, adverse outcomes and possible benefits of supplementation in aged 60 years or over.
Methods: A literature search was performed in PubMed© and Scopus© for all publications from inception published before 15 March 2021. Studies reporting data from aged patients on vitamin D use and COVID-19 were included. Basic science articles, editorials and correspondence were excluded. Publication year, study design and setting, characteristics of the study population were extracted. This study is registered with PROSPERO, under the number CRD42020223993.
Results: In total, 707 studies were identified, of which 11 observational studies were included in the final review. Four studies compared vitamin D-supplemented COVID-19 patients to non-supplemented patients, and seven compared patients with vitamin D deficiency to patients without deficiency. In all four studies, patients with vitamin D supplementation had better rates of primary clinical outcomes (death, the severity of the disease, oxygen therapy requirement…). In studies comparing patients with vitamin D deficiency and patients without vitamin D deficiency, those without vitamin D deficiency had better primary clinical outcomes (death rate, the severity of the disease, oxygen therapy requirement, invasive mechanical ventilation need…).
Conclusion: This systematic review seems to support an association between vitamin D deficiency and the risk of COVID-19 in aged people. In addition, vitamin D deficiency appears to expose these subjects to a greater risk of adverse outcomes. Because of its simplicity of administration, and the rarity of side effects, including vitamin D in preventive strategies for certain viral diseases, it appears to be an attractive option.