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COVID-19 risk reduced by vitamin D supplementation – umbrella review of 7 meta-analysis – Oct 2021

The role of vitamin D in prevention OF COVID-19 and its severity: an umbrella review

Acta Biomed. 2021 Oct 1;92(S6):e2021451. doi: 10.23750/abm.v92iS6.12216.
Lory Marika Margarucci 1, Montanari Enrico 2, Gianluca GIanfranceschi 3, Claudio Caprara 4, Federica Valeriani 5, Antonio Piccolella 6, Valentina Lombardi 7, Elena Scaramucci 8, Vincenzo Romano Spica 9 Italy

Background and aim: Vitamin D is known to modulate immune response and its deficiency was associated with respiratory distress in patients hospitalized for pneumonia. Nevertheless, numerous reviews on vitamin D in COVID-19 patients have shown conflicting results, as previously reported also for other respiratory diseases (e.g., influenza).

Methods: This umbrella review aims to assess whether low serum 25-OHD is associated with susceptibility to COVID 19, their severity, and mortality. A total of 1559 studies were excluded after the title, abstract and full-text articles screening and 9 papers were included in this review: 2 systematic reviews and 7 metanalysis.

Results: The findings of this review that summarized studies from 5 WHO regions (European Region, Region of the Americas, South-East Asia Region, Eastern Mediterranean Region, Western Pacific Region) to exclusion only African region, show that low serum 25-OHD levels are associated with higher infection risks for COVID-19.

Conclusions: Although the umbrella findings indicate a potential role of vitamin D deficiency in COVID-19 severity in hospitalized patients and showing an association between Vitamin D supplementation and COVID-19 severity, however, more robust data from randomized controlled trials are further needed to confirm a possible association with the mortality rates.

References for the above table

  • 29) Akbar MR, Wibowo A, Pranata R, Setiabudiawan B. Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis. Front Nutr 2021; 8, 660420.
  • Bassatne A, Basbous M, Chakhtoura M, El Zein O, Rahme M, El-Hajj Fuleihan G. The link between COVID-19 and Vitamin D (VIVID): A systematic review and meta-analysis. Metabolism 2021; 119, 154753.
  • Dramé M, Cofais C, Hentzien M, Proye E, Coulibaly PS, Demoustier-Tampère D, Destailleur MH, Lotin M, Can- tagrit E, Cebille A, Desprez A, Blondiau F, Kanagaratnam L, Godaert L. Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review. Nutrients 2021; 13(4), 1339.
  • Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Int J Infect Dis 2021; 104, 58-64.
  • Pereira M, Dantas Damascena A, Galvao Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and metaanalysis. Crit Rev Food Sci Nutr 2020; 4, 1-9.
  • Petrelli F, Luciani A, Perego G, Dognini G, Colombelli PL, Ghidini A. Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and metaanalysis of 43 observational studies. J Steroid Biochem Mol Biol 2021; 211, 105883.
  • Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM 2021; 114(3), 175-181.
  • Teshome A, Adane A, Girma B, Mekonnen ZA. The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Front Public Health 2021; 9, 624559.
  • 37) Yisak H, Ewunetei A, Kefale B, Mamuye M, Teshome F, Ambaw B, Yideg Yitbarek G. Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review. Risk Manag Healthc Policy 2021; 14, 31-38.

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