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Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020

The effects of Vitamin D on acute viral respiratory infections: a rapid review - Aug 2020

Ryan Bradley bradley at nunm.edu 1, Janet Schloss* 3,4, Danielle Brown' Deisy Celis2/ John Finnell' Rita Hedol Vladyslav Honcharov2/ Traci Pantuso' Hilda Pena2, Romy Lauche3' Amie Steel3 1Helfg Ott Research Institute,

Clinical significance:
Despite several positive systematic reviews and meta-analyses, the available experimental evidence related to the effects of vitamin D on acute respiratory tract infection (ARTI) is plagued with heterogeneity and mixed quality, and therefore is insufficient to recommend vitamin D supplementation to the general population as a protective agent against ARTI. However, based on the evidence identified in this rapid review (including a high margin of clinical safety), combined with strong mechanistic rationale, the following recommendations can be made for those at risk of ARTI:

  • 1. vitamin D status should be tested for those at risk of ARTI;
  • 2. patients identified with deficiency or insufficiency should be supplemented with vitamin D until their status is normalized; and
  • 3. daily dosing of vitamin D3 is preferred to achieve serum concentrations > 30 nmol/L in a timely manner.

Clinical trials support vitamin D doses of 800 IU/day up to 10,000 lU/day with 1,000 - 2,000 lU/day being a common dosing strategy in clinical trials, and potentially more effective then lower daily or bolus dosing strategies.

VitaminDWiki comments on study

 Download the PDF from VitaminDWiki
Huge range of amount of Vitamin D given: as low as 40 IU

  • Sorry, unable to extract text from this PDF without lots of errors
    • Perhaps the watermark was too intense
  • PDF is extremely conservative: the goal of >13 ng
    • Most health studies conclude that people need > 30ng,
    • Some studies conclude that the goal should be > 50 ng
  • They incorrectly assume that the common dosing strategy is a good dosing strategy
  • This study, like many previous studies, found that a single large (bolus) dose when not followed up with maintenance dosing, does not help.

Respiratory Tract Infection risk reduced 2X by Vitamin D loading doses – meta-analysis Jan 2021

Items in both categories Breathing and Virus are listed here:

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Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

Breathing items with ACUTE in title

This list is automatically updated

Items found: 15
Title Modified
Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2021 30 Sep, 2023
Small doses of vitamin D do not reduce risk of Acute Respiratory Infection - meta-analysis Feb 2022 15 Feb, 2022
Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020 24 Sep, 2021
Small vitamin D doses provide small benefits for acute respiratory infections – Meta-analysis March 2021 31 Mar, 2021
Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021 20 Mar, 2021
Acute respiratory distress – 100 percent of patients were vitamin D deficient– April 2015 09 Jun, 2019
Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017 09 Aug, 2017
Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014 16 Sep, 2016
Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012 15 May, 2016
Acute respiratory infection worsened by too infrequent vitamin D supplementation – RCT June 2015 17 Dec, 2015
Common cold (Acute Rhinosinusitis) 12 percent more likely for every 10 nanogram lower Vitamin D – Oct 2015 13 Oct, 2015
Low dose Vitamin D during pregnancy and infancy results in strange acute respiratory infection response – April 2015 24 Mar, 2015
Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012 20 Mar, 2015
Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 20 Mar, 2015
100 percent of Acute Respiratory Failure patients had low vitamin D - April 2012 21 Jun, 2013

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Created by admin. Last Modification: Saturday February 26, 2022 18:12:10 GMT-0000 by admin. (Version 17)

Attached files

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14215 T2 umbrella.jpg admin 25 Aug, 2020 15:15 190.70 Kb 504
14214 The effects of Vitamin D on acute viral respiratory infections - a rapid review_compressed.pdf PDF 2020 admin 25 Aug, 2020 14:56 232.10 Kb 502