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Risk of COVID-19 death was 4.9 X higher if very low vitamin D – March 31, 2021

Aging Clin Exp Res. 2021 Mar 31. doi: 10.1007/s40520-021-01831-0
Abdullah M Alguwaihes # 1, Shaun Sabico # 2, Rana Hasanato 3, Mohammed E Al-Sofiani 4 5 6, Maram Megdad 7, Sakhar S Albader 8, Mohammad H Alsari 8, Ali Alelayan 8, Ebtihal Y Alyusuf 4, Saad H Alzahrani 9, Nasser M Al-Daghri 2, Anwar A Jammah 4


Mortality and Virus studies (study on this page is #17)

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Purpose: As the world continues to cautiously navigate its way through the coronavirus disease 2019 (COVID-19) pandemic, several breakthroughs in therapies and vaccines are currently being developed and scrutinized. Consequently, alternative therapies for severe acute respiratory coronavirus 2 (SARS-CoV-2) prevention, such as vitamin D supplementation, while hypothetically promising, require substantial evidence from countries affected by COVID-19. The present retrospective case-control study aims to identify differences in vitamin D status and clinical characteristics of hospitalized patients screened for SARS-CoV-2, and determine associations of vitamin D levels with increased COVID-19 risk and mortality.

Methods: A total of 222 [SARS-CoV-2 (+) N = 150 (97 males; 53 females); SARS-CoV-2 (-) N = 72 (38 males, 34 females)] out of 550 hospitalized adult patients screened for SARS-CoV-2 and admitted at King Saud University Medical City-King Khalid University Hospital (KSUMC-KKUH) in Riyadh, Saudi Arabia from May-July 2020 were included. Clinical, radiologic and serologic data, including 25(OH)D levels were analyzed.

Results: Vitamin D deficiency (25(OH)D < 50 nmol/l) was present in 75% of all patients. Serum 25(OH)D levels were significantly lower among SARS-CoV-2 (+) than SARS-CoV-2 (-) patients after adjusting for age, sex and body mass index (BMI) (35.8 ± 1.5 nmol/l vs. 42.5 ± 3.0 nmol/l; p = 0.037). Multivariate regression analysis revealed that significant predictors for SARS-CoV-2 include age > 60 years and pre-existing conditions (p < 0.05). Statistically significant predictors for mortality adjusted for covariates include male sex [Odds ratio, OR 3.3 (95% confidence interval, CI 1.2-9.2); p = 0.02], chronic kidney disease [OR 3.5 (95% CI 1.4-8.7); p = 0.008] and severe 25(OH)D deficiency (< 12.5 nmol/l), but at borderline significance [OR 4.9 (95% CI (0.9-25.8); p = 0.06].

Conclusion: In hospital settings, 25(OH)D deficiency is not associated with SARS-CoV-2 infection, but may increase risk for mortality in severely deficient cases. Clinical trials are warranted to determine whether vitamin D status correction provides protective effects against worse COVID-19 outcomes.

Created by admin. Last Modification: Thursday April 1, 2021 01:32:57 GMT-0000 by admin. (Version 4)

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15358 COVID death risk factors.jpg admin 01 Apr, 2021 01:29 40.73 Kb 65
15357 Low D COVID-19 mortality.pdf PDF 2021 admin 01 Apr, 2021 01:24 906.20 Kb 11
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