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More COVID mortality if less than 20 ng of Vitamin D (Mexico) – May 2022


Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19

Erick J. Martínez-Rodríguez1*, Juan Gutiérrez-Mejía1, Camilo Ríos-Castañeda2, Sonia Rojas-Maya3, Adrián Soto-Mota1
Gac Med Mex. 2022;158:31-35
1Department of Hospital Reaction for Disasters, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”;
2Neurochemistry Department, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”;
3Clinical Laboratory Department, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”. Mexico City, Mexico
*Correspondence: Erick J. Martínez-Rodríguez. E-mail: erickmarrod99 at gmail.com

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Introduction: One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome.

Objective: To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19.

Methods: Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them.

Results: A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19 (age: HR = 1.036, 95% CI = 1.016-1.058, p < 0.001; vitamin D: HR (≤ 20 ng/mL and > 20 ng/mL) = 0.478, 95% CI = 0.237-0.966, p < 0.040).

Conclusion: Age and vitamin D concentration were predictive factors for mortality in COVID-19-infected patients.
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Created by admin. Last Modification: Friday May 27, 2022 15:00:37 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
17670 COVID Mortality Spanish.pdf admin 27 May, 2022 362.39 Kb 217
17669 COVID Survival.jpg admin 27 May, 2022 17.49 Kb 246
17668 COVID Vit D Enslish.pdf admin 27 May, 2022 362.39 Kb 241