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COVID-19 mortality not associated with Vitamin D (everyone had very low levels) -Sept 2021

Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study

Postgrad Med J . 2021 Sep 6; doi: 10.1136/postgradmedj-2021-140564
Mansoor Zafar 1, Mangala Karkhanis 2, Muhammad Shahbaz 2, Alisha Khanna 2, Lucinda Barry 2, Saba Alam 2, Kamal Lawrence 2, Bipin Pun 2, Reem Eldebri 2, Opeyemi Makanjuola 2, Dana Safarova 2, Mariya Farooq 2, Hesam Nooredinavand 2, Frderic Cuison 2, Karuna Subba 3, Ratan Singh Randhawa 2, Johannes Hegner 2, Ojofeitimi Oluwamayowa 2, Amr Elyasaky 4, Bolurin Adekunle 2, Manivannan Periasamy 2, Mohamed Abdelbagi 2, Zahra Maryam 2, Bao Khuu 5, Andreia Esteves Morete 2, Giulio Ciroi 5, Steve Moran 6, William O'Neill 7, Maaryah J Zafar 8, Nadiyah Zafar 8, Mirej Patel 9, Raphael Golez 4, Abubakr Hadid 10, Tila Muhammad 11, Philip Mayhead 12, Mark Whitehead 13, Umesh Dashora 14


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 Download the PDF from VitaminDWiki

Background: The role of vitamin D in increased mortality with SARS-COV-2 virus, namely, COVID-19, remains uncertain. We analysed all the patients who were treated as COVID-19-positive with or without a positive swab and were tested for vitamin D levels.

Methods: This was a retrospective, study involving 1226 patients swabbed for SARS-CoV-2 between the 10 February 2020 and 1 May 2020 at two hospitals of East Sussex Healthcare NHS Trust. Patients who were swab-positive for COVID-19 or treated as COVID-19-positive on clinical grounds even though swab results were negative were included in this study. We analysed the association of vitamin D levels and mortality, assessing linear and non-linear associations.

Results: A total of 1226 patients had SARS-CoV-2 RNA swabs in this period with age range from 1 year to 101 years. A cohort of 433 of these patients had swabs and recent vitamin D levels anytime in the previous 3 months. Mortality rates were not found to be associated with vitamin D levels (OR=1.04, 95% CI 0.96 to 1.12).

Conclusion: Our findings suggest similar mortality risk from COVID-19 irrespective of the levels of vitamin D. Larger prospective studies will be needed to confirm these findings.

Created by admin. Last Modification: Tuesday September 7, 2021 19:44:01 GMT-0000 by admin. (Version 2)

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