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Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis - Dec 2021

Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

Front Public Health. 2021 Dec 22;9:736665. doi: 10.3389/fpubh.2021.736665. eCollection 2021.
Iacopo Chiodini 1 2, Davide Gatti 3, Davide Soranna 4, Daniela Merlotti 5, Christian Mingiano 5, Angelo Fassio 3, Giovanni Adami 3, Alberto Falchetti 6, Cristina Eller-Vainicher 7, Maurizio Rossini 3, Luca Persani 1 2, Antonella Zambon 4 8, Luigi Gennari 5 Italy

Background: Several studies suggest an association between serum 25-hydroxyvitamin D (25OHD) and the outcomes of Severe Acute Respiratory Syndrome Corona-Virus-2 (SARS-CoV-2) infection, in particular Coronavirus Disease-2019 (COVID-19) related severity and mortality. The aim of the present meta-analysis was to investigate whether vitamin D status is associated with the COVID-19 severity, defined as ARDS requiring admission to intensive care unit (ICU) or mortality (primary endpoints) and with the susceptibility to SARS-CoV-2 and COVID-19-related hospitalization (secondary endpoints).

Methods: A search in PubMed, ScienceDirect, Web of Science, Google Scholar, Scopus, and preprints repositories was performed until March 31th 2021 to identify all original observational studies reporting association measures, or enough data to calculate them, between Vitamin D status (insufficiency <75, deficiency <50, or severe deficiency <25 nmol/L) and risk of SARS-CoV-2 infection, COVID-19 hospitalization, ICU admission, or death during COVID-19 hospitalization.

Findings: Fifty-four studies (49 as fully-printed and 5 as pre-print publications) were included for a total of 1,403,715 individuals. The association between vitamin D status and SARS-CoV2 infection, COVID-19 related hospitalization, COVID-19 related ICU admission, and COVID-19 related mortality was reported in 17, 9, 27, and 35 studies, respectively.
Severe deficiency, deficiency and insufficiency of vitamin D were all associated with

  • ICU admission (odds ratio [OR], 95% confidence intervals [95%CIs]: 2.63, 1.45-4.77; 2.16, 1.43-3.26; 2.83, 1.74-4.61, respectively),
  • mortality (OR, 95%CIs: 2.60, 1.93-3.49; 1.84, 1.26-2.69; 4.15, 1.76-9.77, respectively),
  • SARS-CoV-2 infection (OR, 95%CIs: 1.68, 1.32-2.13; 1.83, 1.43-2.33; 1.49, 1.16-1.91, respectively) and
  • COVID-19 hospitalization (OR, 95%CIs 2.51, 1.63-3.85; 2.38, 1.56-3.63; 1.82, 1.43-2.33).

Considering specific subgroups (i.e., Caucasian patients, high quality studies, and studies reporting adjusted association estimates) the results of primary endpoints did not change.

Interpretations: Patients with low vitamin D levels present an increased risk of ARDS requiring admission to intensive care unit (ICU) or mortality due to SARS-CoV-2 infection and a higher susceptibility to SARS-CoV-2 infection and related hospitalization.
 Download the PDF from VitaminDWiki


Odds Ratio data in tabular form

deficiency insufficiency
ICU admission 2.632.16 2.83
Mortality2.601.84 4.15
Infection 1.681.831.49

Founder of VitaminDWiki finds it strange that insufficiency has worse odds ratio than deficiency in the first 2 rows

VitaminDWiki - Vitamin D meta-analyses of Virus

Created by admin. Last Modification: Thursday February 2, 2023 16:21:39 GMT-0000 by admin. (Version 10)

Attached files

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16866 54 studies.jpg admin 10 Jan, 2022 40.98 Kb 479
16865 Vit D COVID 54 studies.pdf admin 10 Jan, 2022 1.56 Mb 341