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COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

The Journal of Steroid Biochemistry and Molecular Biology, https://doi.org/10.1016/j.jsbmb.2021.105883
Fausto Petrellia faupe at libero.IT, Andrea Luciania Gianluca Peregob Giuseppina Dogninic Paolo Luigi Colombellic Antonio Ghidinid

VitaminDWiki

This study assumed that vitamin D for bone health should be applied to COVID-19 (< 20ng)
The human body needs different levels of vitamin D to fight different health problems
For example, need 50 ng to fight Infections
Human bodies appear to need at least 40 ng to fight COVID-19
The study mentions that vitamin D supplementation
   (for any dose size, any duration), reduced risk of severe COVID-19 by 3.7 X


This study was the 10th Vitamin D and COVID-19 meta-analysis in VitaminDWiki

COVID-19 treated by Vitamin D - studies, reports, videos

As of Jan 31, 2024, the VitaminDWiki COVID page had:  19+ trial results,   37+ meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Highlights

  • Vitamin D modulates the systemic inflammatory response through interaction with immune system.
  • We systematically reviewed studies about vitamin D3 and risk and mortality for COVID-19 infection
  • Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection.

Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95% confidence interval (OR 95% CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients.

We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95% CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95% CI, 1.84-3.67; P <  .01 and OR = 1.22; 95% CI, 1.04-1.43; P <  .01, respectively).

Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.


Created by admin. Last Modification: Friday June 25, 2021 14:48:34 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
15390 Meta 43.pdf admin 07 Apr, 2021 947.46 Kb 259
15331 Meta observations.jpg admin 27 Mar, 2021 54.19 Kb 443