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COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021

COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis

Nutrients Oct 14, 2021 doi: https://doi.org/10.1101/2021.09.22.21263977
Lorenz Borsche, Bernd Glauner, Julian von Mendel

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Background Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

Methods Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex and diabetes. Data were analyzed using correlation and linear regression.

Results One population study and seven clinical studies were identified, which reported D3 blood levels pre-infection or on the day of hospital admission. They independently showed a negative Pearson correlation of D3 levels and mortality risk (r(17)=-.4154, p=.0770/r(13)=-.4886, p=.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/ml (17.4 – 26.8), and a significant Pearson correlation was observed (r(32)=-.3989, p=.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/ml D3.

Conclusions The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

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Created by admin. Last Modification: Tuesday October 19, 2021 15:48:56 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
16449 Extra final_compressed.pdf admin 18 Oct, 2021 16:01 451.77 Kb 25
16313 Mortality 50 ng.jpg admin 28 Sep, 2021 19:44 41.17 Kb 402
16312 COVID mortality 50 ng preprint.pdf PDF 2021 admin 28 Sep, 2021 19:43 645.82 Kb 25
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