Toggle Health Problems and D

Ivermectin taken before COVID decreased death rate by 68 percent (3,000 with Ivermectin vs 3,000 without) - Dec 24, 2021

Ivermectin Prophylaxis Used for COVID-19 Reduces COVID-19 Infection and Mortality Rates: A City-Wide, Prospective Observational Study of 220,517 subjects Using Propensity Score Matching.

ResearchGate preprint
Take vs not take Ivermectin 2 days in a row every 15 days in a Brazilian City to prevent serious COVID
   dose of 0.2mg/kg/day
   7% decrease in infection
   56% decrease in hospitalization
   68% decrease in death
This is not placebo-controlled, but did use Propensity Score Matching
Propensity Scores are useful if there are no hidden biases

Lucy Kerr, MD, ARDMS1, Flavio A. Cadegiani, MD, MSc, PhD2,3, Fernando Baldi,
PhD4, Raysildo Barbosa Lobo, PhD5, Washington Luiz Olivato Assagra6, Fernando Carlos
Proeja7, Pierre Kory, MD, MPA3, Jennifer A. Hibberd, DDS, DPD, MRCDC8, Juan J
9 instituto Kerr de Ensino e Pesquisa, Sao Paulo, Brazil
2Corpometria Institute, Brasilia, Brazil
3Front-Line Covid-19 Critical Care Alliance (FLCCC), USA
4Department of Animal Sciences, State University of Sao Paulo, Sao Paulo, Brazil
5Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
6Centro Técnico de Avalia9ao Genomica C.T.A.G, Ribeirao Preto, Brazil
7Itajaí City Hall, Itajaí, Brazil
8University of Toronto, Toronto, Canada
9Data Analysis, Universidad EAFIT, Cambridge, USA

Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both COVID-19 infection and COVID-19-related comorbidities. Based on the studies suggesting efficacy in prophylaxis combined with the known safety profile of ivermectin, a citywide prevention program using ivermectin for COVID-19 was implemented in Itajai, a Southern city in Brazil in the state of Santa Catarina. The objective of this study was to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.

Materials and methods: We analyzed data from a prospective, observational study of the citywide COVID-19 prevention with ivermectin program which occurred between July 2020 to December of 2020 in Itajai, Brazil. Study design, institutional review board approval, and analysis of registry data occurred after completion of the program. The program consisted of inviting the entire population of Itajai to a medical visit in order to enroll in the program and to compile baseline, personal, demographic and medical information. In the absence of contraindications, ivermectin was offered as an optional treatment to be taken 2 consecutive days every 15 days at a dose of 0.2mg/kg/day. In cases where a participating citizen of Itajai became ill with COVID-19, they were recommended to not use ivermectin or any other medication in early outpatient treatment. Clinical outcomes of infection, hospitalization, and death were automatically reported and entered into the registry in real time. Study analysis consisted of comparing ivermectin users with non-users using cohorts of infected patients propensity score matched (PSM) by age, sex, and comorbidities. COVID-19 infection and mortality rates were analyzed with and without use of propensity score matching.

Results: A total of 220,517 subjects were included in the analysis; 133,051 (60.3%) regular ivermectin users and 87,466 (39.7%) non-users. Using PSM, two cohorts of 3,034 subjects suffering COVID-19 infection were compared. The regular use of ivermectin led to a 68% reduction in COVID-19 mortality [25 (0.8%) versus 79 (2.6%) among ivermectin non-users; risk ratio (RR), 0.32; 95% confidence interval (CI), 0.20 - 0.49; p < 0.0001]. When adjusted for residual variables, reduction in mortality rate was 70% (RR, 0.30; 95%CI 0.19 - 0.46; p < 0.0001). There was a 56% reduction in hospitalization rate (44 versus 99 hospitalizations among ivermectin users and non-users, respectively; RR, 0.44; 95%CI, 0.31 - 0.63; p < 0.0001). After adjustment for residual variables, reduction in hospitalization rate was 67% (RR, 0.33; 95%CI 023 - 0.66; p < 0.0001).
 Download the preprint PDF from VitaminDWiki

VitaminDWiki pages with IVERMECTIN in title (8 as of Jan 2022)

This list is automatically updated

Items found: 8

Created by admin. Last Modification: Thursday January 20, 2022 01:43:09 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
16852 Ivermectin Brazil.jpg admin 06 Jan, 2022 01:48 111.65 Kb 178
16851 Brazil Prophylacticivermectin.Updatedversion.Dec242021..pdf PDF 2021 admin 06 Jan, 2022 01:47 771.13 Kb 22
See any problem with this page? Report it (WORKS NOV 2021)