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COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021

Vitamin D supplementation and Covid-19 outcomes: A systematic review, meta-analysis and meta-regression

Reviews in Medical Virology https://doi.org/10.1002/rmv.2269
Timotius Ivan Hariyanto,Denny Intan,Joshua Edward Hananto,Harapan Harapan,Andree Kurniawan

Vitamin D has many protective properties and potential role against acute lung injury. Low serum vitamin D is associated with high risk of pneumonia and development of acute respiratory distress syndrome. This study sought to analyse the efficacy of vitamin D in improving the outcomes of coronavirus disease 2019 (Covid-19) patients. Using specific keywords, we comprehensively searched the potential articles on PubMed, Europe PMC and ClinicalTrials.gov database until 8th May 2021. All published studies on Covid-19 and vitamin D were retrieved. Statistical analysis was conducted using Review Manager 5.4 software. A total of 11 studies with 22,265 Covid-19 patients were included in the meta-analysis. Our data suggested that vitamin D supplementation was associated with

  • reduction in intensive care unit admission rate (OR 0.27; 95% CI: 0.09–0.76, p = 0.010, I2 = 70%, random-effect modelling);
  • reduction of the need for mechanical ventilation (OR 0.34; 95% CI: 0.16–0.72, p = 0.005, I2 = 61%, random-effect modelling) and
  • reduction of mortality from Covid-19 (OR 0.37; 95% CI: 0.21–0.66, p < 0.001, I2 = 50%, random-effect modelling).

Further analysis showed that the associations were influenced by age (p = 0.020). Our study suggests that vitamin D supplementation may offer beneficial effects on Covid-19 outcomes. However, more randomized clinical trials are required to confirm this conclusion.

ICU Risk


Mortality Risk



This meta-analysis,like most others, ignores dose size
It also ignores if Vitamin D had been taken before or after entering hospital

Vitamin D meta-analyses for COVID-19

COVID-19 treated by Vitamin D - studies, reports, videos

5 most-recently changed Virus entries

 Download the PDF from VitaminDWiki

Dosing:(subset of table in the PDF)


Created by admin. Last Modification: Wednesday June 30, 2021 13:43:14 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
15855 ICU Meta.jpg admin 30 Jun, 2021 24.70 Kb 491
15854 Mortality Meta.jpg admin 30 Jun, 2021 37.16 Kb 459
15853 Dose Meta.jpg admin 30 Jun, 2021 93.13 Kb 475
15852 Supplementation COVID meta-analysis.pdf admin 30 Jun, 2021 1.13 Mb 457