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Less COVID-19 infection, mortality in countries with higher Vitamin D (Asia in this case) – May 2021

Impact of the vitamin D deficiency on COVID-19 infection and mortality in Asian countries

Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Vol15, Issue 3, May–June 2021, Pages 757-764 https://doi.org/10.1016/j.dsx.2021.03.006
Ranil Jayawardena ab Dhanushy a T.Jeyakumar cd Tormalli V.Francisc AnoopMisr ae
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Background and aims
COVID-19 is a pandemic that has affected beyond 100 million and caused nearly 3 million deaths globally. Vitamin D is a known risk factor for COVID-19. Therefore, we aimed to investigate the association of prevalence of vitamin D deficiency and mean vitamin D level with COVID-19 infection and mortality in Asia, predicting with other confounding factors such as median age, obesity, and diabetes.

Methods
COVID-19 infections and mortalities among the Asian countries were retrieved from the Worldometer website. Information on prevalence of vitamin D deficiency and mean vitamin D values in each Asian country was retrieved through literature searching on PubMed® and Google scholar. The associations between COVID-19 infections and mortalities with prevalence of vitamin D deficiency and mean vitamin D level were explored with correlation coefficients. As a predictive analysis, multiple linear regression was carried out with all confounders.

Results
Positive correlations were observed for prevalence of vitamin D deficiency with COVID-19 infections (r = 0.55; p = 0.01; R2 = 0.31) and mortalities (r = 0.50; p = 0.01; R2 = 0.25). Moreover, the associations for the COVID-19 infections and mortalities improved to r = 0.76 (p = 0.002; R2 = 0.58) and r = 0.65 (p = 0.03; R2 = 0.42), respectively, after predicting with confounding factors. Similarly, mean vitamin D level had a significant negative correlation with COVID-19 infections (r = −0.77; p = 0.04; R2 = 0.59) and mortalities (r = −0.80; p = 0.03; R2 = 0.63) when combining with confounders.

Conclusion
Prevalence of vitamin D deficiency is significantly positively associated whereas the mean vitamin D level is significantly negatively associated with both infection and mortality rate of COVID-19 among Asian countries upon predicting with all confounders.


Created by admin. Last Modification: Tuesday August 17, 2021 20:31:44 GMT-0000 by admin. (Version 8)

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17520 Mortality vs D clipped.jpg admin 28 Apr, 2022 38.24 Kb 269
15387 Infections vs D.jpg admin 07 Apr, 2021 33.85 Kb 1240
15384 Mortality vs D.jpg admin 07 Apr, 2021 43.82 Kb 766
15383 COVID-19 Assia.pdf admin 07 Apr, 2021 872.97 Kb 393