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COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020

Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION https://doi.org/10.1080/10408398.2020.1841090
Marcos Pereira3, Alialdo Dantas Damascenab, Laylla Mirella Galvao Azevedob, Tarcio de Almeida Oliveira3, and Jerusa da Mota Santanac

  • aCollective Health Institute, Federal University of Bahia, Salvador, Brazil;
  • bCenter of Biological and Health Sciences, Universidade Federal do Oeste da Bahia, Barreiras, Brazil;
  • cSchool of Nutrition, Federal University of Bahia, Salvador, Brazil

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1.7 X increased risk of Severe COVID-19


There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases: Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI =0.80-1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30-2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41-2.21)

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Created by admin. Last Modification: Saturday November 28, 2020 13:51:43 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
14537 Objective and results.jpg admin 05 Nov, 2020 200.73 Kb 398
14536 Meta supplemental.docx admin 05 Nov, 2020 374.94 Kb 303
14535 Death.jpg admin 05 Nov, 2020 31.63 Kb 374
14534 Occurrence.jpg admin 05 Nov, 2020 41.76 Kb 415
14533 Meta B.jpg admin 05 Nov, 2020 58.37 Kb 388
14532 Meta A.jpg admin 05 Nov, 2020 239.83 Kb 428
14531 Meta-Analysis COVID-19.pdf admin 05 Nov, 2020 1.87 Mb 383