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COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021


The effect of vitamin D supplementation on mortality and Intensive Care Unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression

Diabetes Metab Res Rev. 2021 Dec 29;e3517. doi: 10.1002/dmrr.3517
Nikolaos Tentolouris 1, Georgia Samakidou 1, Ioanna Eleftheriadou 1, Anastasios Tentolouris 1, Edward B Jude 2

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Aims: The aim of this systematic review and meta-analysis was to investigate the effect of vitamin D supplementation on mortality and admission to intensive care unit (ICU) of COVID-19 patients.

Methods: A systematic search of PubMed, Google Scholar, Embase, Web of Science and medRxiv with terms relative to vitamin D supplementation and COVID-19 was conducted on March, 26th , 2021. Comprehensive Meta-Analysis software was used for the quantitative assessment of data and random-effects model was applied. To investigate the association between the dose of vitamin D and the outcomes of interest, meta-regression analysis was performed.

Results: 2,078 patients from 9 studies with data on mortality were included (583 received vitamin D supplementation, while 1,495 did not). 61 (10.46%) individuals in the treated group died, compared to 386 (25.81%) in the non-treated group [odds ratio (OR): 0.597; 95% CI: 0.318-1.121; p=0.109]. 860 patients from 6 studies with data on ICU admission were included (369 received vitamin D supplementation, while 491 did not).

45 (12.19%) individuals in the treated group were admitted to ICU, compared to 129 (26.27%) in the non-treated group (OR: 0.326; 95%CI: 0.149-0.712; p=0.005). No significant linear relationship between vitamin D dose and log OR of mortality or log OR of ICU admission was observed.

Conclusion: This meta-analysis indicates a beneficial role of vitamin D supplementation on ICU admission, but not on mortality, of COVID-19 patients. Further research is urgently needed to understand the benefit of vitamin D in Covid-19.
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VitaminDWiki VIRUS category with ICU in title

This list is automatically updated

Items found: 21
Title Modified
Elderly who had been in COVID ICU were 4X more likely to die if low vitamin D – Nov 2022 23 Jul, 2022
COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021 01 May, 2022
Hypothesis: 2 long-haul COVIDs: had mild symptoms and had needed ICU - April 2022 15 Apr, 2022
2.9 X less risk of COVID ICU if seniors had supplemented with Vitamin D (any amount) – April 2022 14 Apr, 2022
Vitamin D supplementation reduced risk of COVID-19 ICU by 2.8 X – review of 10 reviews Feb 2022 16 Feb, 2022
COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021 25 Dec, 2021
COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021 19 Oct, 2021
High-dose Omega-3 fought COVID in 2 hospital trials (6x reduction in ICU, reduced time) – Masterjohn Oct 2021 14 Oct, 2021
Vitamin D while in COVID-19 ICU does not help (no surprise) – July 2021 23 Jul, 2021
7X less likely to go to ICU if COVID-19 ward gave calcifediol (semi-activated Vitamin D) – July 2021 08 Jul, 2021
COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021 30 Jun, 2021
600,000 IU of Vitamin D helped 26 out of 28 COVID-19 patients in ICU (Brazil and Bolivia) June 2021 22 Jun, 2021
COVID-19 ICU survival rate increased 7X by daily Omega-3 – RCT March 2021 18 Apr, 2021
6X less risk of COVID-19 ICU if Vitamin D and Vit B12 and Mg – Jan 2021 16 Apr, 2021
All COVID-19 in ICU had low vitamin D, no difference in outcome if low vs very low – Feb 2021 24 Feb, 2021
5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021 13 Feb, 2021
COVID-19 plus pneumonia in ICU with low vitamin D equaled Death - Dec 2020 04 Jan, 2021
Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June - Sept 26, 2020 04 Dec, 2020
Admission to COVID-19 ICU 1.7X more likely to have less than 20 ng of vitamin D – Sept 2020 17 Sep, 2020
ICU was 2X less likely for COVID-19 hospitalization if Vitamin D more than 20 ng – July 2020 06 Jul, 2020
Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020 30 Apr, 2020

VitaminDWiki - Meta-analysis of VIRUS

Attached files

ID Name Comment Uploaded Size Downloads
16829 ICU 3X full.jpg admin 30 Dec, 2021 01:47 464.41 Kb 215
16828 ICU 3X.jpg admin 30 Dec, 2021 01:46 84.51 Kb 256
16827 ICU 3X trimmed.jpg admin 30 Dec, 2021 01:46 96.86 Kb 198
16826 COVID ICU 3X vitamin D_compressed.pdf PDF 2021 admin 30 Dec, 2021 01:45 494.58 Kb 100
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