Vaccinations did not stop COVID (68 studies) – meta-analysis May 2023

Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up to December, 2022

Lancet Respir Med . 2023 May;11(5):439-452. doi: 10.1016/S2213-2600(23)00015-2
Nana Wu 1, Keven Joyal-Desmarais 1, Paula A B Ribeiro 2, Ariany Marques Vieira 1, Jovana Stojanovic 3, Comfort Sanuade 1, Doro Yip 2, Simon L Bacon 4

• 1 META Group, Montreal Behavioural Medicine Centre, CIUSSS du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada; Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada.
• 2 META Group, Montreal Behavioural Medicine Centre, CIUSSS du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada.
• 3 META Group, Montreal Behavioural Medicine Centre, CIUSSS du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada; Canadian Agency for Drugs and Technologies in Health, Ottawa, ON, Canada.
• 4 META Group, Montreal Behavioural Medicine Centre, CIUSSS du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada; Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada. Electronic address: simon.bacon at concordia.ca.

Background: Synthesising evidence on the long-term vaccine effectiveness of COVID-19 vaccines (BNT162b2 [Pfizer-BioNTech], mRNA-1273 [Moderna], ChAdOx1 nCoV-19 [AZD1222; Oxford-AstraZeneca], and Ad26.COV2.S [Janssen]) against infections, hospitalisations, and mortality is crucial to making evidence-based pandemic policy decisions.

Methods: In this rapid living systematic evidence synthesis and meta-analysis, we searched EMBASE and the US National Institutes of Health's iSearch COVID-19 Portfolio, supplemented by manual searches of COVID-19-specific sources, until Dec 1, 2022, for studies that reported vaccine effectiveness immediately and at least 112 days after a primary vaccine series or at least 84 days after a booster dose. Single reviewers assessed titles, abstracts, and full-text articles, and extracted data, with a second reviewer verifying included studies. The primary outcomes were vaccine effectiveness against SARS-CoV-2 infections, hospitalisations, and mortality, which were assessed using three-level meta-analytic models. This study is registered with the National Collaborating Centre for Methods and Tools, review 473.

Findings: We screened 16 696 records at the title and abstract level, appraised 832 (5·0%) full texts, and initially included 73 (0·4%) studies. Of these, we excluded five (7%) studies because of critical risk of bias, leaving 68 (93%) studies that were extracted for analysis. For infections caused by any SARS-CoV-2 strain, vaccine effectiveness for the primary series reduced from 83% (95% CI 80-86) at baseline (14-42 days) to 62% (53-69) by 112-139 days. Vaccine effectiveness at baseline was 92% (88-94) for hospitalisations and 91% (85-95) for mortality, and reduced to 79% (65-87) at 224-251 days for hospitalisations and 86% (73-93) at 168-195 days for mortality. Estimated vaccine effectiveness was lower for the omicron variant for infections, hospitalisations, and mortality at baseline compared with that of other variants, but subsequent reductions occurred at a similar rate across variants. For booster doses, which covered mostly omicron studies, vaccine effectiveness at baseline was 70% (56-80) against infections and 89% (82-93) against hospitalisations, and reduced to 43% (14-62) against infections and 71% (51-83) against hospitalisations at 112 days or later. Not enough studies were available to report on booster vaccine effectiveness against mortality.

Interpretation: Our analyses indicate that vaccine effectiveness generally decreases over time against SARS-CoV-2 infections, hospitalisations, and mortality. The baseline vaccine effectiveness levels for the omicron variant were notably lower than for other variants. Therefore, other preventive measures (eg, face-mask wearing and physical distancing) might be necessary to manage the pandemic in the long term.
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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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44 Meta-analyses of Virus

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VitaminDwiki COVID infections and vaccinations decrease Vitamin D – many studies

Vaccination

• COVID vaccinations resulted in big increase in metabolic disorders - Nov 2023
• COVID vaccination health problems - Campbell, Yale Nov 2023
• Hypothesis: Multiple COVID vaccinations reduce Vitamin D, resulting in Excess Deaths, etc. - Oct 2023
• Following COVID vaccination 31% had neurological problems (Italy) – Oct 2023
• Autoimmune diseases caused in first day after COVID Vaccination - Oct 2023
• Immune System tolerance is inversely related to the number of COVID vaccinations (PubMed analysis) - Oct 2023
• Hospital utilization Australia (NSW) 1415 Vaccinated, 0 unvaccinated - Dec 2022
• Vaccinated children have more health problems – any vaccination, not just COVID
• Multiple COVID vaccinations might increase Cancer Incidence - many studies
• Vaccine Clinical Trial - cardiovascular death 3.7X more likely if vaccinated - preprint Sept 2023
• Myocarditis, Pericarditis 2X more likely if had COVID vaccination in previous 30 days - meta-analysis June 2023
• COVID Vaccinations increased risk of cardiac deaths in youths by 19% - Aug 2023
• 800x Higher Incidence of Myocardial Injury After Booster Vaccination - July 2023
• 74% of autopsies were found to be related to COVID vaccination (from 44 studies) – Lancet July 2023
• More psoriasis flares following second COVID vaccination if lowish Vitamin D – May 2023
• Long-COVID 2.2X more-likely if had 2 COVID vaccinations - Dec 2022

Vaccination and/or Infection

• COVID infections or vaccinations may increase Multiple Sclerosis (if low D) - several studies
• 50% increase in Cancer deaths (age 15-44) since before COVID - Nov 2023
• Early puberty during pandemic (low vitamin D) - several studies
• Excess deaths - 5 possible reasons - many studies
• Low heart rate variability (bad) is associated with low Vitamin D and COVID – many studies
• T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
• Hepatitis normally rare in children: huge increase after lockdown (Adenovirus, low Vitamin D) - April 2022
• Increased risk of many neuro problems after COVID (1.4 X youths, 1.2X seniors) – Aug 2022
• COVID increased seniors risk of Alzheimer's by 1.7X in the next year- Sept 2022
• Increase in children with low vitamin D and with tibia fractures during COVID – June 2022
• Athletes who had been COVID infected had lower Vitamin D levels – July 2023
• COVID, Vitamin D, Drs. Grimes and Campbell - Jan 2024 has the following chart

Hypothesis: The body consumes Vitamin D each time the immune system is activated

The "GREEN" person started with a high level of Vitamin D
This assumes no vitamin D supplementation by supplements, sun, etc.